CAS 126128-43-6

6-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-4,6-dihydro-1H-pyrimido[4,5-c][1,2]oxazin-7(3H)-one

Description:

The chemical substance known as "6-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-4,6-dihydro-1H-pyrimido[4,5-c][1,2]oxazin-7(3H)-one," with the CAS number 126128-43-6, is a complex organic compound characterized by its unique structural features. It contains a pyrimido-oxazine core, which contributes to its potential biological activity. The presence of a sugar moiety, specifically a 2-deoxy-β-D-erythro-pentofuranosyl group, suggests that it may exhibit properties similar to nucleosides, potentially influencing its interaction with biological systems. The bis(4-methoxyphenyl) substituent indicates a degree of lipophilicity, which may enhance its membrane permeability. This compound may be of interest in medicinal chemistry due to its structural complexity and potential pharmacological applications. However, detailed studies on its solubility, stability, and biological activity would be necessary to fully understand its characteristics and potential uses in therapeutic contexts.

Formula: C₃₂H₃₃N₃O₇

InChI: InChI=1S/C32H33N3O7/c1-38-25-12-8-23(9-13-25)32(22-6-4-3-5-7-22,24-10-14-26(39-2)15-11-24)40-20-28-27(36)18-29(42-28)35-19-21-16-17-41-34-30(21)33-31(35)37/h3-15,19,27-29,36H,16-18,20H2,1-2H3,(H,33,34,37)/t27-,28+,29+/m0/s1

InChI key: InChIKey=BNRBXABFQCWFGZ-ZGIBFIJWSA-N

SMILES: C(OC[C@H]1O[C@H](C[C@@H]1O)N2C=C3C(NC2=O)=NOCC3)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Synonyms:

• 1H-Pyrimido[4,5-c][1,2]oxazin-7(3H)-one, 6-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl]-4,6-dihydro-
• 6-(5-O-(Dimethoxytrityl)-Beta-D-2-Deoxyribofuranosyl)-3,4-Dihydro-8H-Pyrimido-{4,5-C}{1,2}Oxazin7One
• 6-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl]-4,6-dihydro-1H-pyrimido[4,5-c][1,2]oxazin-7(3H)-one
• 6-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-4,6-dihydro-1H-pyrimido[4,5-c][1,2]oxazin-7(3H)-one
• 1H-Pyrimido[4,5-c][1,2]oxazin-7(3H)-one, 6-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-4,6-dihydro-
• 6-(5-O-(Dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido-[4,5-c][1,2]oxazin-7-one
• 6-(β-D-5-O-(4,4'-Dimethoxytrityl)-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one
• 6-(β-D-5-O-(4,4’-Dimethoxytrityl)-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one
• one
• 6-(5-O-(Dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-
• 6-(2-Deoxy-5-O-DMT-b-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido-[4,5-c][1,2]oxazin-7-one
• 3,4-dihydro-8H-pyrimido-[4,5-c][1,2]oxazin-7-

6-(β-D-5-O-(4,4'-Dimethoxytrityl)-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one

CAS: 126128-43-6

Nucleoside Derivatives - Bi-/Tricyclic nucleosides; Protected nucleosides w/NH2/OH open

Formula: C₃₂H₃₃N₃O₇

Color and Shape: Solid

Molecular weight: 571.62

Ref: TM-TNU1296

6-(2-Deoxy-5-O-DMT-b-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido-[4,5-c][1,2]oxazin-7-one

CAS: 126128-43-6

6-(2-Deoxy-5-O-DMT-b-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido-[4,5-c][1,2]oxazin-7-one is a synthetic diphosphate that is active as an activator of phosphoramidites. It has shown anticancer activity in vitro and in vivo. This compound has been shown to inhibit the DNA synthesis of tumor cells and to be effective against viruses such as herpes simplex virus type 1 and 2 (HSV1 and HSV2). 6-(2-Deoxy-5-O-DMT b -D ribofuranosyl)-3,4 -dihydro 8H pyrimido [4,5 c ][1,2]oxazin 7 one also inhibits the replication of RNA viruses such as influenza A virus (IAV), human immunodeficiency virus

Formula: C₃₂H₃₅N₃O₇

Purity: Min. 95%

Molecular weight: 573.64 g/mol

Ref: 3D-ND145589