CAS 126222-34-2

Remikiren

Description:

Remikiren is a chemical compound classified as a non-peptide inhibitor of the enzyme neprilysin, which plays a crucial role in the degradation of various peptides, including natriuretic peptides. Its primary application is in the field of cardiovascular medicine, particularly for the treatment of hypertension and heart failure. Remikiren is characterized by its ability to enhance the levels of beneficial peptides in the body, thereby promoting vasodilation and diuresis. The compound has a specific molecular structure that contributes to its activity as an inhibitor, and it is typically administered in a pharmaceutical formulation. As with many pharmacological agents, its efficacy and safety profile are evaluated through clinical trials, and it may exhibit side effects or interactions with other medications. The compound's development reflects ongoing research into innovative therapies for managing cardiovascular diseases, highlighting the importance of neprilysin inhibition in therapeutic strategies.

Formula: C₃₃H₅₀N₄O₆S

InChI: InChI=1S/C33H50N4O6S/c1-33(2,3)44(42,43)20-25(16-22-10-6-4-7-11-22)31(40)37-28(18-26-19-34-21-35-26)32(41)36-27(17-23-12-8-5-9-13-23)30(39)29(38)24-14-15-24/h4,6-7,10-11,19,21,23-25,27-30,38-39H,5,8-9,12-18,20H2,1-3H3,(H,34,35)(H,36,41)(H,37,40)/t25-,27+,28+,29+,30-/m1/s1

InChI key: InChIKey=UXIGZRQVLGFTOU-VQXQMPIVSA-N

SMILES: [C@H](NC([C@H](CC1=CN=CN1)NC([C@H](CC2=CC=CC=C2)CS(C(C)(C)C)(=O)=O)=O)=O)(CC3CCCCC3)[C@H]([C@@H](O)C4CC4)O

Synonyms:

• Ro 42-5892
• (αS)-N-[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-α-[[(2S)-2-[[(1,1-dimethylethyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-1H-imidazole-5-propanamide
• 1H-Imidazole-4-propanamide, N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-α-[[(2S)-2-[[(1,1-dimethylethyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-, (αS)-
• 1H-Imidazole-4-propanamide, N-[1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-α-[[2-[[(1,1-dimethylethyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-, [1S-[1R*[R*(R*)],2S*,3R*]]-
• 1H-Imidazole-5-propanamide, N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-α-[[(2S)-2-[[(1,1-dimethylethyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-, (αS)-

Remikiren

CAS: 126222-34-2

Remikiren is a highly specific renin inhibitor with oral activity for the treatment of hypertensio.

Formula: C₃₃H₅₀N₄O₆S

Color and Shape: Solid

Molecular weight: 630.84

Ref: TM-T34285

Remikiren

Controlled Product

CAS: 126222-34-2

Applications Remikiren, is a renin inhibitor under development for the treatment of hypertension (high blood pressure).
References Richter, W. F., et al.: Xenobiotica, 26 (3), 243 (1996);

Formula: C₃₃H₅₀N₄O₆S

Color and Shape: Neat

Molecular weight: 630.838

Ref: TR-R143550

Remikiren-d4

Controlled Product

CAS: 126222-34-2

Formula: C₃₃D₄H₄₆N₄O₆S

Color and Shape: Neat

Molecular weight: 634.863

Ref: TR-R143552

Remikiren

CAS: 126222-34-2

Remikiren is an angiotensin receptor blocker that blocks the binding of angiotensin II to its receptors on cells. It is used to treat high blood pressure and congestive heart failure. Remikiren has been shown to have a low potency in vitro, but it is more potent in vivo and has greater efficacy than losartan at doses of 100 mg/kg/day. This drug also has biochemical properties that are similar to those of other inhibitors of the renin-angiotensin system, such as ACE inhibitors and AT1 antagonists. Remikiren significantly reduces the level of angiotensin II in animals with experimental cardiac disease, which may be due to its ability to inhibit cytokine production by macrophages.

Formula: C₃₃H₅₀N₄O₆S

Purity: Min. 95%

Molecular weight: 630.8 g/mol

Ref: 3D-BFA22234