Manidipine dihydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. The substance is characterized by its dihydrochloride salt form, which enhances its solubility and bioavailability. Manidipine is known for its long-lasting antihypertensive effects, allowing for once-daily dosing. In addition to its primary action on blood vessels, it may also exhibit some cardioprotective properties. The compound is typically administered orally and is well-tolerated, though potential side effects can include dizziness, headache, and peripheral edema. Its pharmacokinetics involve extensive hepatic metabolism, and it is important to monitor for interactions with other medications that may affect its efficacy or safety. Overall, Manidipine dihydrochloride is a valuable therapeutic agent in managing cardiovascular conditions.

Manidipine hydrochloride is another second-generation dihydropyridine calcium
antagonist introduced as an antihypertensive. In animal studies, manidipine
hydrochloride dose-dependently decreased systolic pressure with potent and
long-lasting effects. It has little cardiodepressant activity and its claimed to be useful in hypertensive patients without the fear of cardiac failure or severe
bradycardia.

Manidipine dihydrochloride

126229-12-7: Manidipine dihydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. The substance is characterized by its dihydrochloride salt form, which enhances its solubility and bioavailability. Manidipine is known for its long-lasting antihypertensive effects, allowing for once-daily dosing. In addition to its primary action on blood vessels, it may also exhibit some cardioprotective properties. The compound is typically administered orally and is well-tolerated, though potential side effects can include dizziness, headache, and peripheral edema. Its pharmacokinetics involve extensive hepatic metabolism, and it is important to monitor for interactions with other medications that may affect its efficacy or safety. Overall, Manidipine dihydrochloride is a valuable therapeutic agent in managing cardiovascular conditions.

CAS 126229-12-7

Manidipine dihydrochloride

Manidipine Hydrochloride RS

Ref: 2K-1155000021