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CAS 12627-35-9

:

Penitrem A

Description:
Penitrem A is a mycotoxin produced by certain species of fungi, particularly from the Penicillium genus. It is characterized by its complex polycyclic structure, which includes multiple fused rings and various functional groups, contributing to its biological activity. This compound is known for its neurotoxic effects, primarily affecting the central nervous system of mammals. Penitrem A has been studied for its potential to induce tremors and seizures in animals, highlighting its significance in toxicology. It is soluble in organic solvents, which facilitates its extraction from contaminated materials. Due to its toxic nature, Penitrem A poses risks in agricultural settings, particularly in relation to contaminated feed and food products. Regulatory agencies monitor its presence to ensure safety in food supplies. Research continues to explore its mechanisms of action and potential implications for human health, as well as its environmental impact. Overall, Penitrem A serves as a critical example of the importance of understanding mycotoxins in both ecological and health contexts.
Formula:C37H44ClNO6
InChI:InChI=1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1
InChI key:InChIKey=JDUWHZOLEDOQSR-JKPSMKLGSA-N
SMILES:O[C@]12[C@]34[C@](O3)([C@@H](O)[C@@H](C(C)=C)O[C@]4(CC[C@]1(C)[C@@]5(C)C6=C7[C@]([C@@]5(CC2)[H])(OC(C)(C)[C@@]8([C@@]9(O)C%10=C7C(N6)=CC(Cl)=C%10CC(=C)[C@]9(C8)[H])[H])[H])[H])[H]
Synonyms:
  • (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-Chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
  • (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8S,9aR,14bS,14cR,16aS)-12-chloro-14b,14c,17,17-tetramethyl-10-methylidene-2-(prop-1-en-2-yl)-3,3a,6,6a,7,8,9,9a,10,11,14,14b,14c,15,16,16a-hexadecahydro-2H,4bH-7,8-(epoxymethano)cyclobuta[5,6]benzo[1,2-e]oxireno[4',4a']chromeno[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H)-triol
  • (2R,3S,3aS,4aR,4bS,6aR,7S,8S,9aR,14bS,14cR,16aS)-12-chloro-14b,14c,17,17-tetramethyl-10-methylidene-2-(prop-1-en-2-yl)-3,3a,6,6a,7,8,9,9a,10,11,14,14b,14c,15,16,16a-hexadecahydro-2H,4bH-7,8-(epoxymethano)cyclobuta[5,6]benzo[1,2-e]oxireno[4',4a']chromeno[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H)-triol
  • 7,8-(Epoxymethano)-2H,4bH-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole, penitrem A deriv.
  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-
  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, [2R-(2α,3α,3aα,4aS*,4bβ,6aα,7α,7dβ,8β,9aβ,14bβ,14cα,16aβ)]-
  • NSC 354845
  • Penitrem A
  • Tremortin A
  • [2R-(2α,3α,3aα,4aS*,4bβ,6aα,7α,7dβ,8β,9aβ,14bβ,14cα,16aβ)]-12-Chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
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Found 5 products.
  • Penitrem A
    Glentham
    + Info

    Penitrem A

    CAS:
    Formula:C37H44ClNO6
    Molecular weight:634.20

    Ref: 7W-GP4643

    ne
    To inquire
  • Penitrem A from Penicillium paxilli
    Apollo Scientific
    + Info

    Penitrem A from Penicillium paxilli

    CAS:
    Penitrem A from Penicillium paxilli
    Formula:C37H44ClNO6
    Purity:By hplc: 97.53% (Typical Value in Batch COA)
    Color and Shape: white powder
    Molecular weight:634.20g/mol

    Ref: 54-BIP1006

    1mg
    97.00€
    5mg
    300.00€
    10mg
    521.00€
    25mg
    1,120.00€
    50mg
    1,854.00€
    100mg
    3,334.00€
  • Penitrem A
    Targetmol
    + Info

    Penitrem A

    CAS:
    <p>Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.</p>
    Formula:C37H44ClNO6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:634.2

    Ref: TM-T12403

  • Penitrem A, Penicillium paxilli
    Fluorochem
    + Info

    Penitrem A, Penicillium paxilli

    CAS:
    <p>M02244 - Penitrem A, Penicillium paxilli</p>
    Formula:C37H44ClNO6
    Purity:>90%
    Molecular weight:634.21

    Ref: 10-M02244

    1mg
    127.00€
  • Penitrem A
    Biosynth
    + Info

    Penitrem A

    CAS:
    <p>Penitrem A is a potent mycotoxin, which is a secondary metabolite produced predominantly by the fungi of the genus *Penicillium*, particularly *Penicillium crustosum*. It operates primarily as a tremorgenic compound, affecting the neuromuscular systems through interference with neurotransmitter release mechanisms. Penitrem A achieves this by blocking calcium channels and modulating the function of neurotransmitter release sites at nerve terminals, leading to its characteristic effects on the nervous system.</p>
    Purity:Min. 95%

    Ref: 3D-BP162742

    1mg
    303.00€
    5mg
    989.00€
    10mg
    1,491.00€