Calcifediol-d3, also known as 25-hydroxyvitamin D3, is a metabolite of vitamin D3 (cholecalciferol) and plays a crucial role in calcium and phosphate metabolism in the body. It is a fat-soluble vitamin that is primarily produced in the liver from vitamin D3 after its conversion by hydroxylation. The substance is characterized by its ability to bind to vitamin D receptors, influencing gene expression related to calcium absorption and bone health. Calcifediol-d3 is often used in clinical settings to assess vitamin D status and can be administered as a supplement to treat or prevent vitamin D deficiency. Its chemical structure includes a steroid backbone with hydroxyl groups that enhance its solubility and biological activity. As a compound, it is stable under normal conditions but may degrade under extreme temperatures or in the presence of light. Its pharmacokinetics involve conversion to the more active form, calcitriol, which exerts various physiological effects, including modulation of immune function and cellular growth.

Calcifediol-d3

1262843-45-7: Calcifediol-d3, also known as 25-hydroxyvitamin D3, is a metabolite of vitamin D3 (cholecalciferol) and plays a crucial role in calcium and phosphate metabolism in the body. It is a fat-soluble vitamin that is primarily produced in the liver from vitamin D3 after its conversion by hydroxylation. The substance is characterized by its ability to bind to vitamin D receptors, influencing gene expression related to calcium absorption and bone health. Calcifediol-d3 is often used in clinical settings to assess vitamin D status and can be administered as a supplement to treat or prevent vitamin D deficiency. Its chemical structure includes a steroid backbone with hydroxyl groups that enhance its solubility and biological activity. As a compound, it is stable under normal conditions but may degrade under extreme temperatures or in the presence of light. Its pharmacokinetics involve conversion to the more active form, calcitriol, which exerts various physiological effects, including modulation of immune function and cellular growth.

Applications A labelled metabolite of Vitamin D. The principal circulating form of vitamin D3, formed in the liver by hydroxylation at C-25. Calcium regulator. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Morii, et al.: Arch. Biochem. Biophys., 120, 513 (1967), Blunt, et al.: Biochemistry, 7, 3317 (1968), Liu, et al.: Science, 311, 1770 (2006),

CAS 1262843-45-7

Calcifediol-d3

Calcifediol-d3

Ref: TR-C125701