CAS 1263-89-4: Paromomycin sulfate

Description:Paromomycin sulfate is an aminoglycoside antibiotic primarily used to treat infections caused by certain types of bacteria, particularly in cases of intestinal amebiasis and leishmaniasis. It is derived from the bacterium Streptomyces griseus and functions by inhibiting protein synthesis in susceptible microorganisms. The compound is characterized by its ability to bind to the 30S ribosomal subunit, leading to misreading of mRNA and ultimately disrupting bacterial growth. Paromomycin is typically administered orally or parenterally, depending on the infection being treated. It is known for its relatively low toxicity compared to other aminoglycosides, although it can still cause side effects such as gastrointestinal disturbances and nephrotoxicity in some cases. The sulfate form enhances its solubility in water, making it suitable for various formulations. Paromomycin is also being investigated for its potential use in treating multidrug-resistant infections, highlighting its importance in the field of antimicrobial therapy.

Formula:C₂₃H₄₅N₅O₁₄·xH₂O₄S

InChI:InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key:InChIKey=LJRDOKAZOAKLDU-UDXJMMFXSA-N

SMILES:O=S(=O)(O)O.OCC1OC(OC2C(OC3OC(CO)C(OC4OC(CN)C(O)C(O)C4N)C3O)C(O)C(N)CC2N)C(N)C(O)C1O

Synonyms:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside sulfate (salt)
(2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
1600 Antibiotic
4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxyhexopyranosyl)-D-lyxofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside sulfate (salt)
D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
Aminosidin sulfate
Aminosidin sulphate
See more synonyms
Aminosidine Sulphate
Aminosidine sulfate
Aminoxidin
D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (1:?)
D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
Farmiglucin
Farminosidin
Fi 5853
Gabbroral
Humagel
Humatin
Humycin sulfate
O-2-Amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptamine sulfate (salt)
Paramicina
Pargonyl
Paricina
Paromomycin Sulphate
Paromomycin Sulphates
Paromomycin sulfate salt
Paromomycinsulfate
Sinosid
Sulfates De Paromomycine
Sulfatos De Paromomicina
D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
Paromomycin sulfate

Found 16 products.

Product data	Purity	Price range	Estimated delivery
Paromomycin Sulfate REF: 3B-P2092CAS: 1263-89-4 7542-37-2 84420-34-8	>92.0%(HPLC)	45.00 €~139.00 €	Mon 07 Apr 25
Paromomycin sulfate REF: 02-J61274CAS: 1263-89-4	- - -	To inquire	Tue 08 Apr 25
Paromomycin sulfate RS REF: 41-ICRS0378CAS: 1263-89-4	- - -	102.00 €	Mon 14 Apr 25
Paromomycin Sulfate REF: 45-1500003CAS: 1263-89-4	- - -	480.00 €	Tue 15 Apr 25
Paromomycin Sulfate REF: TM-T1104CAS: 1263-89-4	99.73% - 99.86%	48.00 €	Mon 14 Apr 25
Paromomycin sulfate salt REF: IN-DA0072SFCAS: 1263-89-4	%	To inquire	Mon 14 Apr 25
Paromomycin sulphate REF: 54-BIP0141CAS: 1263-89-4	Ph - 6 loss on drying: 3.1% (Typical Value in Batch COA)	37.00 €~191.00 €	Tue 15 Apr 25
Paromomycin Sulfate REF: 54-BUP18626CAS: 1263-89-4	99.86%	69.00 €	Tue 15 Apr 25
Paromomycin sulfate salt REF: 7W-GA4947CAS: 1263-89-4	- - -	33.00 €~243.00 €	Tue 15 Apr 25
Paromomycin sulfate REF: 04-C15893500CAS: 1263-89-4	- - -	74.00 €	Thu 17 Apr 25
Paromomycin Sulfate REF: 4Z-P-413001CAS: 1263-89-4	- - -	To inquire	Mon 21 Apr 25
Paromomycin Sulfate REF: TR-P205650CAS: 1263-89-4	- - -	102.00 €~513.00 €	Thu 24 Apr 25
Paromomycin sulfate, Antibiotic for Culture Media Use Only REF: 3D-Q-201537CAS: 1263-89-4	Min. 95.0 Area-%	To inquire	Fri 25 Apr 25
Paromomycin sulfate REF: 3D-AP31110CAS: 1263-89-4	≥675Μg/Mg(On Dried Basis)	227.00 €~2,224.00 €	Fri 25 Apr 25
Paromomycin Sulfate (PRM) REF: SR-27436CAS: 1263-89-4	- - -	48.00 €~454.00 €	Mon 12 May 25
PAROMOMYCIN SULFATE REF: 10-F806731CAS: 1263-89-4	95%	- - -	Discontinued product