CAS 1263-89-4

Paromomycin sulfate

Description:

Paromomycin sulfate is an aminoglycoside antibiotic primarily used to treat infections caused by certain types of bacteria, particularly in cases of intestinal amebiasis and leishmaniasis. It is derived from the bacterium Streptomyces griseus and functions by inhibiting protein synthesis in susceptible microorganisms. The compound is characterized by its ability to bind to the 30S ribosomal subunit, leading to misreading of mRNA and ultimately disrupting bacterial growth. Paromomycin is typically administered orally or parenterally, depending on the infection being treated. It is known for its relatively low toxicity compared to other aminoglycosides, although it can still cause side effects such as gastrointestinal disturbances and nephrotoxicity in some cases. The sulfate form enhances its solubility in water, making it suitable for various formulations. Paromomycin is also being investigated for its potential use in treating multidrug-resistant infections, highlighting its importance in the field of antimicrobial therapy.

Formula: C₂₃H₄₇N₅O₁₈S

InChI: InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23?;/m1./s1

InChI key: InChIKey=LJRDOKAZOAKLDU-UDXJMMFXSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N

Synonyms:

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside sulfate (salt)
• (2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• 1600 Antibiotic
• 4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxyhexopyranosyl)-D-lyxofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Aminosidin sulfate
• Aminosidin sulphate
• Aminosidine Sulphate
• Aminosidine sulfate
• Aminoxidin
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Farmiglucin
• Farminosidin
• Fi 5853
• Gabbroral
• Humagel
• Humatin
• Humycin sulfate
• O-2-Amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptamine sulfate (salt)
• Paramicina
• Pargonyl
• Paricina
• Paromomycin Sulphate
• Paromomycin Sulphates
• Paromomycin sulfate salt
• Paromomycinsulfate
• Sinosid
• Sulfates De Paromomycine
• Sulfatos De Paromomicina
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• Paromomycin sulfate
• D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI)
• fi5853
• PayoMoMycin Sulfate
• Paromomycin sulphate solution,1000ppm solution
• Barone sulfate kanamycin Solution, 100ppm
• humycinsulfate
• Humatin (tn)
• Paromomycin sulfate (jan/usp)
• O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate
• sulf
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy-, sulfate (salt) (8CI)
• Paromomycin sulphate solution,100ppm
• aminosidinesulfate
• PAROMOMYCIN SULFATE CELL CULTURE REAGENT 97+%
• Paromomycin Sulfate (125 mg)
• paromomycin sulfate cell culture tested
• Paromomycin Sufate
• paromomycin sulfate plant cell*culture tested
• streptamine,o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribof
• NEOMYCIN E
• aminosidinesulphate
• Paramomycinsulfate
• O-2,6-DiaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-aMino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-StreptaMine Sulfate
• aminosidinsulfate
• O-2-AMino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptaMine Sulfate
• D00868
• PAROMOMYCIN SULFATE USP 97+%
• Paromomycin sulfate ,98%
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1)

Paromomycin Sulfate

CAS: 1263-89-4, 7542-37-2, 84420-34-8

Formula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Purity: >92.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Ref: 3B-P2092

Paromomycin sulfate

CAS: 1263-89-4

Inhibits initiation and elongation during protein synthesis

Formula: C₂₃H₄₇N₅O₁₈S

Color and Shape: White to pale cream to pale yellow, Powder

Molecular weight: 713.71

Ref: 02-J61274

PAROMOMYCIN SULFATE RS

CAS: 1263-89-4

PAROMOMYCIN SULFATE RS

Formula: C₂₃H₄₅N₅O₁₄

Molecular weight: 615.6285

Ref: 41-ICRS0378

Paromomycin Sulfate

CAS: 1263-89-4

Aminoglycoside antibiotics

Formula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Color and Shape: White Off-White Light Yellow Powder

Molecular weight: 615.2963

Ref: 45-1500003

Paromomycin sulfate

CAS: 1263-89-4

Formula: C₂₃H₄₇N₅O₁₈S

Purity: 98%

Color and Shape: Solid

Molecular weight: 713.7070

Ref: IN-DA0072SF

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate, an aminoglycoside antibiotic, binds to 30S ribosomes, disrupting protein synthesis and killing bacteria.

Formula: C₂₃H₄₇N₅O₁₈S

Purity: 99.73% - 99.86%

Color and Shape: Solid

Molecular weight: 713.71

Ref: TM-T1104

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate

Purity: ≥98%

Molecular weight: 713.71g/mol

Ref: 54-BUP18626

Paromomycin sulfate salt

CAS: 1263-89-4

Formula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Color and Shape: White to off-white powder

Molecular weight: 713.71

Ref: 7W-GA4947

Paromomycin sulphate

CAS: 1263-89-4

Paromomycin sulphate

Formula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Purity: Ph - 6 loss on drying: 3.1% (Typical Value in Batch COA)

Color and Shape: white to faint yellow powder

Molecular weight: 713.71g/mol

Ref: 54-BIP0141

Paromomycin sulfate

Controlled Product

CAS: 1263-89-4

Formula: C₂₃H₄₅N₅O₁₄·H₂O₄S

Color and Shape: Neat

Molecular weight: 713.71

Ref: 04-C15893500

Paromomycin Sulfate

CAS: 1263-89-4

Stability Hygroscopic
Applications an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Formula: C₂₃H₄₅N₅O₁₄·H₂O₄S

Color and Shape: Neat

Molecular weight: 713.71

Ref: TR-P205650

Paromomycin sulfate

CAS: 1263-89-4

Paromomycin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating intestinal infections and leishmaniasis.

Formula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Purity: ≥675Μg/Mg(On Dried Basis)

Color and Shape: Yellow Powder

Molecular weight: 615.63 g/mol

Ref: 3D-AP31110

Paromomycin sulfate, Antibiotic for Culture Media Use Only

CAS: 1263-89-4

Paromomycin sulfate is an antibiotic used for culture media to control bacterial contamination of mediums and other laboratory substances. Most Gram-negative bacteria strains are sensitive to paromomycin sulfate, showing a low sensitivity (≀10%) in Enterobacteriaceae, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae and Serratia marcescens. Paromomycin sulfate is also used in the treatment of colorectal cancer by blocking DNA synthesis through inhibition of protein synthesis in susceptible cells. This can result in reduced damage in colon tumor cells within the body, although it may have neurotoxic effects on brain tissue. Furthermore, it has anti-inflammatory properties when given orally or intravenously at therapeutic doses. Acridine orange can be used to identify sulfuric acid resistant gram.

Formula: C₂₃H₄₇N₅O₁₈S

Purity: Min. 95.0 Area-%

Molecular weight: 713.71 g/mol

Ref: 3D-Q-201537

Paromomycin Sulfate (PRM)

CAS: 1263-89-4

Formula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Color and Shape: White to off-white, Powder

Molecular weight: 713.17

Ref: SR-27436

Paromomycin sulfate

CAS: 1263-89-4

Purity: 95+%

Molecular weight: 713.710022

Ref: 10-F806731

Neomycin sulfate EP Impurity E

CAS: 1263-89-4

Formula: C₂₃H₄₅N₅O₁₄H₂SO₄

Molecular weight: 615.63 : 98.07

Ref: ST-EA-CP-N53005