CAS 1263094-00-3

7-Chlorokynurenic acid sodium salt

Description:

7-Chlorokynurenic acid sodium salt is a chemical compound that serves as a potent antagonist of the NMDA (N-methyl-D-aspartate) receptor, which is involved in synaptic plasticity and memory function. This compound is a derivative of kynurenic acid, characterized by the presence of a chlorine atom at the 7-position of the kynurenine structure. As a sodium salt, it is typically more soluble in aqueous solutions, making it suitable for various biological and pharmacological studies. The compound has garnered interest in neuroscience research due to its potential neuroprotective properties and its role in modulating glutamatergic signaling. Additionally, it may have implications in the study of neurodegenerative diseases and psychiatric disorders. Its synthesis and characterization involve standard organic chemistry techniques, and it is often utilized in experimental settings to explore its effects on neuronal activity and behavior. Safety and handling precautions should be observed, as with any chemical substance, particularly in laboratory environments.

Formula: C₁₀H₅CINNaO₃

Synonyms:

• 7-Chloro-4-hydroxyquinoline-2-carboxylicacidsodiumsalt
• 7-CKA sodium salt
• 7-Chlorokynurenic acid sodium salt

7-Chlorokynurenic acid sodium salt

CAS: 1263094-00-3

7-CKA sodium salt: NMDA receptor antagonist, glycine B site (IC50: 0.56 μM), blocks glutamate reuptake (Ki: 0.59 μM).

Formula: C₁₀H₆ClNNaO₃

Color and Shape: Solid

Molecular weight: 246.6

Ref: TM-T10191