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CAS 126313-98-2

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3”-HYDROXY SIMVASTATIN

Description:
3-Hydroxy Simvastatin is a derivative of simvastatin, a well-known statin used primarily for lowering cholesterol levels in the blood. This compound is characterized by the presence of a hydroxyl group at the 3-position of the simvastatin structure, which enhances its solubility and bioavailability compared to its parent compound. It functions as a competitive inhibitor of HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver. The molecular structure includes a lactone ring, which is typical of statins, and it exhibits a high affinity for the target enzyme, leading to a significant reduction in low-density lipoprotein (LDL) cholesterol levels. Additionally, 3-Hydroxy Simvastatin may possess antioxidant properties and has been studied for potential pleiotropic effects beyond cholesterol reduction, such as anti-inflammatory actions. Its pharmacokinetics, including absorption, metabolism, and excretion, are influenced by factors such as food intake and genetic variations in metabolic enzymes. Overall, this compound plays a vital role in cardiovascular health management.
Formula:C25H38O6
InChI:InChI=1/C25H38O6/c1-14-10-17-7-6-15(2)20(9-8-19-12-18(27)13-22(28)30-19)23(17)21(11-14)31-24(29)25(4,5)16(3)26/h6-7,10,14-16,18-21,23,26-27H,8-9,11-13H2,1-5H3/t14?,15-,16?,18+,19+,20-,21?,23-/m0/s1
Synonyms:
  • (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 3-hydroxy-2,2-dimethylbutanoate
  • (Rac)-3′-Hydroxy simvastatin
  • Simvastatin Impurity 8（EP-G）
  • 3-Hydroxy-2,2-diMethylbutanoic Acid
  • Simvastatin beta-Hydroxy Impurity
  • Butanoic acid, 3-hydroxy-2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester
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