CAS 126347-74-8

desacetylnavelbine

Description:

Desacetylnavelbine, with the CAS number 126347-74-8, is a semi-synthetic derivative of the natural product vinblastine, which is derived from the periwinkle plant. This compound is primarily characterized by its role as an antineoplastic agent, meaning it is utilized in cancer treatment due to its ability to inhibit cell division. Desacetylnavelbine exhibits a mechanism of action that involves the disruption of microtubule formation, which is crucial for mitosis, thereby leading to apoptosis in rapidly dividing cancer cells. The compound is known for its improved pharmacological properties compared to its parent compound, including enhanced solubility and bioavailability. It is typically administered in a clinical setting, often in combination with other chemotherapeutic agents, to treat various malignancies, particularly non-small cell lung cancer. As with many chemotherapeutics, its use may be accompanied by side effects, necessitating careful monitoring of patients during treatment. Overall, desacetylnavelbine represents a significant advancement in the development of targeted cancer therapies.

Formula: C₄₃H₅₂N₄O₇

InChI: InChI=1/C43H52N4O7/c1-7-25-18-26-21-42(38(49)53-5,34-28(24-46(22-25)23-26)27-12-9-10-13-31(27)44-34)30-19-29-32(20-33(30)52-4)45(3)36-41(29)15-17-47-16-11-14-40(8-2,35(41)47)37(48)43(36,51)39(50)54-6/h9-14,18-20,26,35-37,44,48,51H,7-8,15-17,21-24H2,1-6H3/t26-,35-,36+,37+,40+,41?,42-,43-/m0/s1

Synonyms:

• C'-Norvincaleukoblastine, O4-deacetyl-3',4'-didehydro-4'-deoxy-
• methyl (2beta,3beta,4beta,5alpha,19alpha)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• Desacetylnavelbine

Aspidospermidine-3-carboxylic acid, 6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3,4-dihydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-

CAS: 126347-74-8

Formula: C₄₃H₅₂N₄O₇

Molecular weight: 736.8956

Ref: IN-DA000SPH

Vinorelbine EP Impurity B (4-O-Deacetylvinorelbine)

CAS: 126347-74-8

Formula: C₄₃H₅₂N₄O₇

Molecular weight: 736.92

Ref: 4Z-V-040004

Deacetyl Vinorelbine-d3 Sulfate

Controlled Product

CAS: 126347-74-8

Stability Hygroscopic
Applications Deacetyl Vinorelbine-d3 Sulfate Salt is a labelled metabolite of Vinorelbine (V315000).
References Elmarakby, S., et al.: J. Med. Chem., 32, 2158 (1989), Jehl, F., et al.: Cancer Res., 51, 2073 (1991), Kajita, J., et al.: Drug Metab. Dispos., 28, 1121 (2000), Puozzo, C., et al.: J. Pharm. Biomed. Anal., 44, 144 (2007),

Formula: C₄₃H₄₉D₃N₄O₇xH₂SO₄

Color and Shape: Neat

Molecular weight: 739.91

Ref: TR-D199013

Vinorelbine EP Impurity B

CAS: 126347-74-8

Formula: C₄₃H₅₂N₄O₇

Molecular weight: 736.92

Ref: ST-EA-CP-V49012

Deacetyl vinorelbine

Controlled Product

CAS: 126347-74-8

Deacetyl vinorelbine is a prodrug that is metabolized to its active form, vinorelbine. It is used in the treatment of cancer and lung cancer. Deacetyl vinorelbine is converted by hydrolysis to deacetylvinorelbine, which inhibits the enzyme topoisomerase II and blocks DNA synthesis, leading to cell death. Vinorelbine also inhibits cellular respiration by inhibiting mitochondrial cytochrome c oxidase and blocking electron transfer from cytochrome c to oxygen. The drug binds to human serum albumin with high affinity and has been shown to have a long half-life in humans due to its ability to bind tightly with proteins such as serum albumin. This binding prevents the drug from being eliminated through the kidneys or liver, prolonging its activity in the body.

Formula: C₄₃H₅₂N₄O₇

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 736.9 g/mol

Ref: 3D-FD20831