CAS 1264-72-8

colistin sulfate

Description:

Colistin sulfate, with the CAS number 1264-72-8, is an antibiotic that belongs to the polymyxin class of antibiotics, primarily used to treat infections caused by Gram-negative bacteria. It is derived from the bacterium Bacillus polymyxa and is known for its effectiveness against multidrug-resistant strains. Colistin sulfate is a complex mixture of polypeptides, with colistin A and colistin E being the most prominent components. The substance is characterized by its amphipathic nature, allowing it to disrupt bacterial cell membranes, leading to cell death. Colistin sulfate is typically administered via injection or inhalation, as it is poorly absorbed from the gastrointestinal tract. Its use has been limited due to potential nephrotoxicity and neurotoxicity, prompting careful monitoring during treatment. Despite these concerns, colistin sulfate has regained attention in recent years due to the rise of antibiotic-resistant infections, making it a critical option in the antimicrobial arsenal. Its formulation as a sulfate salt enhances its solubility and stability, facilitating its use in clinical settings.

Formula: (C₅₂H₉₈N₁₆O₁₃)·5(H₂SO₄)

InChI: InChI=1/C52H98N16O13/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t29?,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+/m1/s1

Synonyms:

• Belcomycin
• Colimycin sulfate
• Colistin Sulphate
• Colistin, Sulfat (Salz)
• Colistin, sulfate (salt)
• Colistina, Sulfato (Sal)
• Colistine, Sulfate (Sel)
• Colomycin
• Colomycin syrup
• N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-5-methylheptanamide
• N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]amino}-3-hydroxy-1-oxobutan-2-yl]amino}-1-oxobutan-2-yl]-6-methyloctanamide sulfate (1:1)
• N-[3-Amino-1-[[1-[[3-Amino-1-[[6,9,18-Tris(2-Aminoethyl)-3-(1-Hydroxyethyl)-12,15-Bis(2-Methylpropyl)-2,5,8,11,14,17,20-Heptaoxo-1,4,7,10,13,16,19-Heptazacyclotricos-21-Yl]Carbamoyl]Propyl]Carbamoyl]-2-Hydroxy-Propyl]Carbamoyl]Propyl]-5-Methyl-Heptanamide Sulfate
• Nipoxyme
• Polymyxin E sulfate
• Polymyxin E, sulfate (salt)
• Colistin sulfate
• COLISTIN SULPHATE PURE GRADE
• polymyxine Multimycine
• Colistin sulphate premix 10% 40%
• polymyxinesulfate(salt)
• Colstin sulfate
• colistinsulfat
• Belcomycine
• colomycinsyrup
• COLISTINSULFATE,POWDER,USP
• colimycinsulfate
• COLISTINE SULFATE
• Colistin sulphate premix 10%
• ColistinSulfateEp5
• Colomyci

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate, 1264-72-8, or polymyxin E complex, is a complex of antibiotics, primarily colistin A and B, which has broad-spectrum anti-bacterial activity. Learn more.

Formula: C₅₃H₁₀₂N₁₆O₁₇S

Color and Shape: Powder, White to pale cream

Molecular weight: 1267.55

Ref: 02-J60915

COLISTIN SULFATE FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1264-72-8

COLISTIN SULFATE FOR MICROBIOLOGICAL ASSAY CRS

Formula: C₅₂H₉₈N₁₆O₁₃

Molecular weight: 1155.434

Ref: 41-C2700000

Colistin Sulfate

CAS: 1264-72-8

Antibiotics nesoi

Formula: ColistinAC₅₃H₁₀₀N₁₆O₁₃ColistinBC₅₂H₉₈N₁₆O₁₃

Color and Shape: White Light Yellow Powder

Molecular weight: 1155.434

Ref: 45-1148001

Colistin (sulfate)

CAS: 1264-72-8

Formula: C₅₃H₁₀₂N₁₆O₁₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 1267.5390

Ref: IN-DA000SQS

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

Formula: C₅₃H₁₀₀N₁₆O₁₇S

Purity: 98%

Color and Shape: Powder

Molecular weight: 1253.51

Ref: TM-T1245

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate

Purity: ≥95%

Molecular weight: 1253.51g/mol

Ref: 54-BUP17364

Colistin sulfate salt

CAS: 1264-72-8

Purity: ≥ 19000U/mg (dried basis)

Color and Shape: White to pale yellow, hygroscopic powder

Ref: 7W-GA9867

Colistin A Pentatrifluoroacetate (Polymyxin E1 Pentatrifluoroacetate)

CAS: 1264-72-8, 7722-44-3

Formula: C₅₃H₁₀₀N₁₆O₁₃·5C₂HF₃O₂

Molecular weight: 1169.48 5*114.02

Ref: 4Z-PC-321002

Colistin sulfate salt, Ph. Eur. grade

CAS: 1264-72-8

Purity: ≤ 4.0%

Color and Shape: White or almost white powder

Ref: 7W-GP4890

Colistin sulphate

CAS: 1264-72-8

Colistin sulphate

Formula: C₅₃H₁₀₀N₁₆O₁₃·H₂SO₄

Purity: Sulphate: 17.2%; sulphated (Typical Value in Batch COA)

Color and Shape: Solid

Molecular weight: 1,267.54g/mol

Ref: 54-BIC0118

Colistin sulfate

Controlled Product

CAS: 1264-72-8

Formula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBCH₉₈N₁₆O₁₃·(H₂SO₄)

Color and Shape: Neat

Molecular weight: 1169.46

Ref: 04-C11693500

Colistin sulfate 100 µg/mL in Water

Controlled Product

CAS: 1264-72-8

Formula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBCH₉₈N₁₆O₁₃·(H₂SO₄)

Color and Shape: Single Solution

Molecular weight: 1169.46

Ref: 04-A11693500WA-100

Colistin Sulfate (Mixture of A and B compound)

CAS: 1264-72-8

Ref: 4Z-PC-321001

Colistin Sulfate (Mixture of A and B compound)

Controlled Product

CAS: 1264-72-8

Applications Cyclic polypeptide antibiotic produced by Bacillus polymyxa. Complex mixture of at least 30 components, primarily colistins A and B.[α]D= -65° (c= 1, Water) LOD: 3% DAB= α,γ-diaminobutyric acidHeavy Metals: 20ppm Colistin A R= (+)-6-methyloctanoylArsenic Content: 2ppm/g Colistin B R= 6-methylheptanoylSulfate: 16-18%Biological Potency (dry basis): 19600U/mg
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Suzuki, T., et al.: J. Biochem., 54, 25 (1963), Barnett, M., et al.: Br. J. Pharmacol. Chemother., 23, 552 (1964), Littlewood, J, M., et al.: Respir. Med., 94, 632 (2000), Li, J., et al.: Int. J. Antimicrob. Ag., 25, 11 (2005),

Formula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBC₅₂H₉₈N₁₆O₁₃·(H₂SO₄)

Color and Shape: White To Light Yellow

Molecular weight: 1169.46

Ref: TR-C641500

Colistin sulfate

CAS: 1264-72-8

Colistin is a narrow-spectrum antibiotic efficient mostly against gram-negative bacteria. Colistin interacts with the outer membrane of gram-negative bacteria and induces a transfer of divalent cations of calcium and magnesium from the negatively charged phosphate groups. This causes the disruption of the outer membrane and release of lipopolysaccharides. It is commonly used against Enterobacteriaceae and Aeromonas, and none-fermentative gram-negative bacteria as well as for carbapenem-resistant Acinetobacter strains.

Formula: C₅₃H₁₀₂N₁₆O₁₇S

Purity: Min. 77 Area-%

Color and Shape: White Powder

Molecular weight: 1,266.73 g/mol

Ref: 3D-AC20542

Colistin sulfate, Antibiotic for Culture Media Use Only

CAS: 1264-72-8

Antibacterial agent with the ability to permeate bacterial membranes and cause cell death. Colistin is a cationic peptide also known as polymyxin E. Colistin is effective in multidrug resistant Gram-positive bacteria such as P. aeruginosa, A. baumannii and K. pneumoniae.

Formula: C₅₃H₁₀₂N₁₆O₁₇S

Molecular weight: 1,266.73 g/mol

Ref: 3D-Q-200890

Colistin Sulphate (CLS)

CAS: 1264-72-8

Formula: (C₅₂H₉₈N₁₆O₁₃)·5(H₂SO₄)

Color and Shape: White to pale yellow, Crystalline powder

Molecular weight: 2801.27

Ref: SR-51681