CAS 126518-41-0

enacyloxin IIa

Description:

Enacyloxin IIa is a natural product classified as a polyketide antibiotic, primarily derived from the bacterium *Streptomyces enacyloxinicus*. It exhibits notable antibacterial properties, particularly against Gram-positive bacteria, making it of interest in the field of medicinal chemistry and antibiotic development. The compound features a complex molecular structure characterized by multiple functional groups, including a lactone ring, which contributes to its biological activity. Enacyloxin IIa operates by inhibiting bacterial protein synthesis, thereby impeding the growth and reproduction of susceptible microorganisms. Its mechanism of action and structural uniqueness make it a subject of research for potential therapeutic applications, especially in the context of rising antibiotic resistance. Additionally, studies have indicated that enacyloxin IIa may possess cytotoxic properties, warranting further investigation into its safety and efficacy profiles. Overall, this compound represents a significant area of interest in the search for new antibiotics and the exploration of natural products in drug discovery.

Formula: C₃₃H₄₅Cl₂NO₁₁

InChI: InChI=1/C33H45Cl2NO11/c1-4-5-13-26(47-33(36)45)29(35)24(38)18-25(39)31(42)30(41)20(3)22(34)12-8-6-10-19(2)11-7-9-14-28(40)46-27-17-21(32(43)44)15-16-23(27)37/h5-14,20-21,23-24,26-27,29-31,37-38,41-42H,4,15-18H2,1-3H3,(H2,36,45)(H,43,44)/b8-6+,11-7+,13-5+,14-9+,19-10+,22-12-/t20-,21+,23+,24-,26-,27-,29+,30?,31?/m1/s1

Synonyms:

• Enx iia
• (1S,3R,4S)-3-{[(2E,4E,6E,8E,10Z,12S,17R,18S,19R,20E)-19-(carbamoyloxy)-11,18-dichloro-13,14,17-trihydroxy-6,12-dimethyl-15-oxotricosa-2,4,6,8,10,20-hexaenoyl]oxy}-4-hydroxycyclohexanecarboxylic acid
• enacyloxin IIa
• Cyclohexanecarboxylic acid, 3-((19-((aminocarbonyl)oxy)-11,18-dichloro-13,14,17-trihydroxy-6,12-dimethyl-1,15-dioxo-2,4,6,8,10,20-tricosahexaenyl)oxy)-4-hydroxy-
• Enacyloxin iia
• Cyclohexanecarboxylic acid, 3-[[(2E,4E,6E,8E,10Z,12S,13R,14S,17R,18S,19R,20E)-19-[(aminocarbonyl)oxy]-11,18-dichloro-13,14,17-trihydroxy-6,12-dimethyl-1,15-dioxo-2,4,6,8,10,20-tricosahexaen-1-yl]oxy]-4-hydroxy-, (1R,3S,4R)-

Enacyloxin IIa

CAS: 126518-41-0

Enacyloxin IIa (ENX IIa) is a polyene antibiotic with activity against both Gram-positive and Gram-negative bacteria, while exhibiting weak antifungal properties and no effect on yeast.

Formula: C₃₃H₄₅Cl₂NO₁₁

Color and Shape: Solid

Molecular weight: 702.617

Ref: TM-TN10487