CAS 126544-47-6

Ciclesonide

Description:

Ciclesonide is a synthetic corticosteroid primarily used as an anti-inflammatory agent in the treatment of asthma and allergic rhinitis. It is characterized by its prodrug nature, meaning it is metabolized in the body to its active form, des-ciclesonide, which exerts the therapeutic effects. Ciclesonide has a high affinity for the glucocorticoid receptor, leading to potent anti-inflammatory activity while minimizing systemic side effects. The compound is typically administered via inhalation, allowing for targeted delivery to the lungs, which enhances its efficacy and reduces potential adverse effects associated with systemic corticosteroids. Its chemical structure features a cyclopropyl group and a carbonyl moiety, contributing to its stability and solubility. Ciclesonide is known for its low oral bioavailability, which further limits systemic exposure. Overall, its pharmacokinetic profile, including a long half-life and rapid metabolism, makes it a favorable option in managing respiratory conditions.

Formula: C₃₂H₄₄O₇

InChI: InChI=1/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1

InChI key: InChIKey=LUKZNWIVRBCLON-GXOBDPJESA-N

SMILES: C(COC(C(C)C)=O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@H](O2)[C@H]4CCCCC4)[H])([C@]5([C@]([C@@H](O)C3)([C@]6(C)C(CC5)=CC(=O)C=C6)[H])[H])[H]

Synonyms:

• (11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
• (R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate
• 2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl 2-methylpropanoate
• 2-[(4aR,4bS,5S,6aS,6bS,8R,9aS,10aS,10bS)-8-cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl 2-methylpropanoate
• 2-[(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-8-cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl 2-methylpropanoate
• 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
• Alvesco
• Aservo EquiHaler
• Bi 54903
• Cinase
• Omnaris
• Pregna-1,4-diene-3,20-dione, 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, [11β,16α(R)]-
• Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11β,16α)-
• Rpr 251526
• Ciclesonide
• Ciclesonide containing impurity A CRS
• Ciclesonide CRS
• 2-[(6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-Cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl]-2-oxoethyl Isobutyrate
• Ciclesonide(RPR251526)

CICLESONIDE CONTAINING IMPURITY A CRS

CAS: 126544-47-6

CICLESONIDE CONTAINING IMPURITY A CRS

Formula: C₃₂H₄₄O₇

Molecular weight: 540.6876

Ref: 41-Y0001554

CICLESONIDE CRS

CAS: 126544-47-6

CICLESONIDE CRS

Formula: C₃₂H₄₄O₇

Molecular weight: 540.6876

Ref: 41-Y0001553

Ciclesonide

CAS: 126544-47-6

Formula: C₃₂H₄₄O₇

Molecular weight: 540.69

Ref: 7W-GP7386

Ciclesonide

CAS: 126544-47-6

Ciclesonide

Purity: ≥98%

Molecular weight: 540.69g/mol

Ref: 54-BUP13625

Ciclesonide

CAS: 126544-47-6

Formula: C₃₂H₄₄O₇

Molecular weight: 540.70

Ref: 4Z-C-481002

Ceftazidime EP Impurity B Trifluoroacetate

CAS: 126544-47-6

Formula: C₂₂H₂₂N₆O₇S₂·C₂HF₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 546.57 114.02

Ref: 4Z-C-10502

Ciclesonide

Controlled Product

CAS: 126544-47-6

Formula: C₃₂H₄₄O₇

Color and Shape: Neat

Molecular weight: 540.69

Ref: 04-C11666300

Ciclesonide

Controlled Product

CAS: 126544-47-6

Formula: C₃₂H₄₄O₇

Color and Shape: Neat

Molecular weight: 540.69

Ref: 86-MM3608.00

Ciclesonide 100 µg/mL in Acetonitrile

CAS: 126544-47-6

Formula: C₃₂H₄₄O₇

Color and Shape: Single Solution

Molecular weight: 540.69

Ref: 04-A11666300AL-100

Ciclesonide

CAS: 126544-47-6

Formula: C₃₂H₄₄O₇

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 540.70

Ref: 3B-C3701

Ciclesonide

CAS: 126544-47-6

Ciclesonide (Alvesco)(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.

Formula: C₃₂H₄₄O₇

Purity: 99.89% - >99.99%

Color and Shape: Solid

Molecular weight: 540.69

Ref: TM-T2526

Ciclesonide

Controlled Product

CAS: 126544-47-6

Applications A glucocorticoid microemulsion nasal preparation allergy inhibitor rhinitis.
References Fukuoka, E., et al.: Chem. Pharm. Bull., 35, 2943 (1987), Schmitt, E., et al.: J. Pharm. Sci., 88, 291 (1999), Hancock, B., et al.: Pharm. Res., 17, 397 (2000), Hogan, S., et al.: Pharm. Res., 18, 112 (2001),

Formula: C₃₂H₄₄O₇

Color and Shape: White To Off-White

Molecular weight: 540.69

Ref: TR-C432690

Ciclesonide

Controlled Product

CAS: 126544-47-6

Glucocorticoid; anti-inflammatory; anti-asthmatic agent

Formula: C₃₂H₄₄O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 540.69 g/mol

Ref: 3D-FC20428