CAS 126550-86-5

ALPHA-D-GAL-[1->4]-BETA-D-GAL-[1->4]-BETA-D-GLC-1->O-SPHINGOSINE

Description:

Alpha-D-Gal-[1->4]-Beta-D-Gal-[1->4]-Beta-D-Glc-1->O-Sphingosine, with the CAS number 126550-86-5, is a complex glycosphingolipid. This compound features a sphingosine backbone, which is a long-chain amino alcohol, and is characterized by the presence of sugar moieties, specifically galactose and glucose, linked through glycosidic bonds. The structure indicates that it has multiple sugar units, which contribute to its hydrophilic properties, while the sphingosine portion provides hydrophobic characteristics. This amphiphilic nature allows it to play significant roles in cellular membranes and signaling pathways. Glycosphingolipids like this compound are often involved in cell recognition, signaling, and interactions with other biomolecules. They are also important in the context of various biological processes, including immune response and neuronal function. The specific arrangement of the sugar units and the sphingosine backbone can influence the biological activity and function of this glycosphingolipid in different physiological contexts.

Formula: C₃₆H₆₇NO₁₇

InChI: InChI=1/C36H67NO17/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21(41)20(37)19-49-34-30(47)27(44)32(23(17-39)51-34)54-36-31(48)28(45)33(24(18-40)52-36)53-35-29(46)26(43)25(42)22(16-38)50-35/h14-15,20-36,38-48H,2-13,16-19,37H2,1H3/b15-14+/t20-,21+,22+,23+,24+,25-,26-,27+,28+,29+,30+,31+,32+,33-,34+,35+,36-/m0/s1

Synonyms:

• Globotriaosylsphingosine
• Α-D-Gal-(1→4)-Β-D-Gal-(1→4)-Β-D-Glc-1→O-Sphingosine
• Globotriaosyl Lysosphingolipid
• Globotriaosylsphingosine from porcine blood
• (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside

(2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5R,6S)-6-(((2R,3S,4R,5R,6R)-6-(((2S,3R,E)-2-Amino-3-hydroxyoctadec-4-en-1-yl)oxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-(hydroxyme

CAS: 126550-86-5

(2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5R,6S)-6-(((2R,3S,4R,5R,6R)-6-(((2S,3R,E)-2-Amino-3-hydroxyoctadec-4-en-1-yl)oxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-(hydroxyme

Purity: 97%

Molecular weight: 785.92g/mol

Ref: 54-OR1054394

Lyso-Globotriaosylceramide (d18:1)

CAS: 126550-86-5

Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.

Formula: C₃₆H₆₇NO₁₇

Color and Shape: Solid

Molecular weight: 785.922

Ref: TM-T37291

lyso-Ceramide Trihexoside

CAS: 126550-86-5

Formula: C36H67NO17

Purity: >99%

Color and Shape: Solid

Molecular weight: 785.92

Ref: 48-56-1058

Globotriaosylceramid​e Sphingosine

Controlled Product

CAS: 126550-86-5

Applications Globotriaosylceramid​e Sphingosine tert-Butyldimethylsilyl is a Fabry disease biomarker.
References Dupont, F.O., et. al.: Curr. Med. Chem., 20, 280 (2013); Liao, H., et. al.: Clinica Chimica Acta, 426, 114 (2013)

Formula: C₃₆H₆₇NO₁₇

Color and Shape: Neat

Molecular weight: 785.914

Ref: TR-G410640

Globotriaosylsphingosine

CAS: 126550-86-5

Globotriaosylsphingosine is dramatically increased in plasma of classically affected male Fabry patients and plasma and tissues of Fabry mice. Globotriaosylsphingosine was shown to be an inhibitor of α-galactosidase A activity. Furthermore, exposure of smooth muscle cells, but not fibroblasts, to globotriaosylsphingosine at concentrations observed in plasma of patients promotes proliferation. It was suggested that measurement of circulating globotriaosylsphingosine would be useful to monitor Fabry disease and may contribute to a better understanding of the disorder.

Formula: C₃₆H₆₇NO₁₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 785.91 g/mol

Ref: 3D-OG44865

Lyso-Globotriaosylceramide

CAS: 126550-86-5

Formula: C₃₆H₆₇NO₁₇

Molecular weight: 785.92

Ref: 4Z-C-488003