CAS 126716-28-7

H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH

Description:

The chemical substance known as H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH, with the CAS number 126716-28-7, is a synthetic peptide composed of a sequence of amino acids. This peptide features a combination of glycine (GLY), penicillamine (PEN), arginine (ARG), aspartic acid (ASP), serine (SER), proline (PRO), cysteine (CYS), and alanine (ALA), indicating its potential role in biological processes or therapeutic applications. The presence of cysteine suggests the possibility of disulfide bond formation, which can influence the peptide's three-dimensional structure and stability. The N-terminal modification (H-) indicates that it is a protected form, which may enhance its solubility and bioavailability. Peptides like this one are often studied for their biological activity, including potential roles in signaling pathways, enzyme inhibition, or as therapeutic agents. The specific characteristics, such as solubility, stability, and biological activity, would depend on the peptide's conformation and the environment in which it is studied.

Formula: C₃₅H₅₇N₁₃O₁₄S₂

Synonyms:

• H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH, (Disulfide bond between Pen2 and Cys9)
• L-Alanine, glycyl-3-mercapto-L-valylglycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-L-cysteinyl-, cyclic (2→9)-disulfide
• H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH trifluoroacetate salt (Disulfide bond between Pen? and Cys?)
• H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH
• Pyrrolo[2,1-g][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosine,cyclic peptide deriv
• H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH trifluoroacetate salt (Disulfide bond between Pen2 and Cys)
• H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH (Disulfide bond between Pen2 and Cys?)

H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH

CAS: 126716-28-7

GPenGRGDSPCA (cRGD), a cyclic RGD peptide has been used in the study of vascular wound response. GPenGRGDSPCA caused vasodilation when applied to isolated rat cremaster arterioles. The vasodilation is dependent on interaction of the soluble cRGD sequence with the αvβ3 integrin expressed by smooth muscle cells in the arteriolar wall.

Formula: C₃₅H₅₇N₁₃O₁₄S₂

Purity: 96.3%

Color and Shape: White Lyophilisate

Molecular weight: 948.05

Ref: 01-4027371

H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH trifluoroacetate salt (Disulfide bond between Pen2 and Cys9)

CAS: 126716-28-7

Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys (GPEG) is a peptide that modulates the function of muscle cells and is present in collagen. GPEG has been shown to improve oxidative damage, which occurs during exercise. The effect of GPEG on muscle cells is dependent on the dose. Low doses of GPEG activate proteins that are involved in transcription and increases the synthesis of oxidative enzymes, while high doses inhibit these proteins. GPEG also modulates integrin receptor expression and decreases fibronectin production by vascular smooth muscle cells.

Formula: C₃₅H₅₇N₁₃O₁₄S₂

Purity: Min. 95%

Molecular weight: 948.04 g/mol

Ref: 3D-FG109134