CAS 126727-03-5

N-9-Fluorenylmethoxycarbonyl-DL-leucine

Description:

N-9-Fluorenylmethoxycarbonyl-DL-leucine, commonly referred to as Fmoc-DL-leucine, is a derivative of the amino acid leucine, characterized by the presence of a fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is primarily utilized in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), where the Fmoc group serves as a protective moiety for the amino group of leucine. The Fmoc group is stable under basic conditions and can be removed under mild acidic conditions, allowing for selective deprotection during the synthesis process. Fmoc-DL-leucine is a white to off-white solid, and its solubility is generally good in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), but limited in water. The presence of both L- and D-forms of leucine in this compound allows for versatility in peptide design, making it valuable in the development of various bioactive peptides. Its chemical structure contributes to its stability and reactivity, making it an essential building block in the field of medicinal chemistry and biochemistry.

Formula: C₂₁H₂₃NO₄

InChI: InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)

InChI key: InChIKey=CBPJQFCAFFNICX-UHFFFAOYSA-N

SMILES: C(OC(NC(CC(C)C)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Synonyms:

• Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• DL-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• N-9-Fluorenylmethoxycarbonyl-DL-leucine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]leucine
• N-FMOC-DL-leucine

N-9-Fluorenylmethoxycarbonyl-DL-leucine

CAS: 126727-03-5

Formula: C₂₁H₂₃NO₄

Purity: 97%

Molecular weight: 353.4116

Ref: IN-DA009BXO

DL-Leucine-d10-N-FMOC

CAS: 126727-03-5

Formula: (CD₃)₂CDCD₂CD(NHFMOC)COOH

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 363.48

Ref: 3U-D5753

DL-Leucine-d10-N-FMOC

Controlled Product

CAS: 126727-03-5

Applications DL-Leucine-d10-N-FMOC is a useful isotopically labeled compound

Formula: C₂₁D₁₀H₁₃NO₄

Color and Shape: Neat

Molecular weight: 363.48

Ref: TR-L330172

DL-leucine-d10-N-Fmoc

CAS: 126727-03-5

D-Leucine-d10-N-Fmoc is a cox-2 inhibitor that inhibits the activity of cyclooxygenase enzymes, which are involved in the formation of prostaglandins from arachidonic acid. It has been shown to have an anticancer effect against cells in culture and also inhibits the growth of tumors in mice. D-Leucine-d10-N-Fmoc is a molecule with a structure similar to celecoxib, a selective COX 2 inhibitor that is currently used for treatment of arthritis. However, unlike celecoxib, D-Leucine-d10-N-Fmoc does not inhibit any other isoforms of cyclooxygenase.END>>

Formula: C₂₁H₂₃NO₄

Purity: Min. 95%

Molecular weight: 353.4 g/mol

Ref: 3D-BFA72703