CAS 126750-70-7

5-hydroxyindapamide

Description:

5-Hydroxyindapamide is a chemical compound that belongs to the class of sulfonamide derivatives and is primarily recognized for its pharmacological properties. It is a diuretic agent, often used in the treatment of hypertension and edema associated with various medical conditions. The compound features a hydroxy group (-OH) at the 5-position of the indapamide structure, which contributes to its biological activity. Its molecular structure includes an indole ring fused with a sulfonamide moiety, which is essential for its mechanism of action. 5-Hydroxyindapamide exhibits moderate solubility in water and is typically administered in oral dosage forms. The compound's efficacy is attributed to its ability to inhibit sodium reabsorption in the kidneys, leading to increased urine output and reduced blood pressure. Additionally, it may have other cardiovascular benefits, making it a valuable therapeutic agent. As with many pharmaceuticals, the safety profile and potential side effects should be considered during its use in clinical settings.

Formula: C₁₆H₁₆ClN₃O₄S

InChI: InChI=1/C16H16ClN3O4S/c1-9-6-11-7-12(21)3-5-14(11)20(9)19-16(22)10-2-4-13(17)15(8-10)25(18,23)24/h2-5,7-9,21H,6H2,1H3,(H,19,22)(H2,18,23,24)

SMILES: CC1Cc2cc(ccc2N1N=C(c1ccc(c(c1)S(=O)(=O)N)Cl)O)O

Synonyms:

• Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-5-hydroxy-2-methyl-1H-indol-1-yl)-
• 4-chloro-N-(5-hydroxy-2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide

5-Hydroxy Indapamide

CAS: 126750-70-7

Formula: C₁₆H₁₆ClN₃O₄S

Color and Shape: Solid

Molecular weight: 381.8339

Ref: IN-DA000T7B

5-Hydroxy Indapamide

CAS: 126750-70-7

Formula: C₁₆H₁₆ClN₃O₄S

Color and Shape: Off-White Solid

Molecular weight: 381.84

Ref: 4Z-I-133

Indapamide Impurity 22

CAS: 126750-70-7

Formula: C₁₄H₁₀Cl₂N₂O₇S₂

Color and Shape: Off-White Solid

Molecular weight: 453.26

Ref: 4Z-I-1336

5-Hydroxy Indapamide

Controlled Product

CAS: 126750-70-7

Applications 5-Hydroxy Indapamide is a major metabolite of Indapamide (I500100), and possesses similar antihypertensive and diuretic properties.
References Slater, T., et al.: Biochem. J., 222, 1 (1984), Josephson, R., et al.: J. Biol. Chem., 266, 2354 (1991), Del Rio, M., et al.: Eur. J. Pharm., 250, 133 (1993), Calder, J., et al.: Eur. J. Pharma., 256, 185 (1994),

Formula: C₁₆H₁₆ClN₃O₄S

Color and Shape: Neat

Molecular weight: 381.83

Ref: TR-H943450

5-Hydroxy Indapamide-13C,d3

Controlled Product

CAS: 126750-70-7

Formula: CC₁₅D₃H₁₃ClN₃O₄S

Color and Shape: Neat

Molecular weight: 385.845

Ref: TR-H943452

5-Hydroxy Indapamide

CAS: 126750-70-7

Formula: C₁₆H₁₆ClN₃O₄S

Molecular weight: 381.83

Ref: ST-EA-CP-I21009