CAS 12676-15-2

ANGIOTENSIN IV

Description:

Angiotensin IV is a peptide that plays a significant role in the regulation of blood pressure and fluid balance in the body. It is derived from the angiotensin II peptide through enzymatic cleavage. Angiotensin IV is known to interact with specific receptors, influencing various physiological processes, including vasodilation and modulation of renal function. The substance is characterized by its relatively small molecular size and specific amino acid sequence, which is crucial for its biological activity. It is primarily studied in the context of cardiovascular health and potential therapeutic applications in conditions such as hypertension and heart failure. Additionally, Angiotensin IV has been investigated for its neuroprotective properties and its role in cognitive functions. Its CAS number, 12676-15-2, is a unique identifier that facilitates the identification and study of this compound in scientific literature and databases. Overall, Angiotensin IV is an important molecule in the renin-angiotensin system, contributing to various physiological and pathological processes.

Formula: C₄₀H₅₄N₈O₈

Synonyms:

• (2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
• angiotensin III, 1-desarginine-
• Ang IV, Angiotensin II (3-8)
• Angiotensin IV trifluoroacetate salt

Angiotensin II (3-8), human

CAS: 12676-15-2

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.

Color and Shape: Solid

Ref: TM-T5824

Angiotensin IV Trifluoroacetate

CAS: 12676-15-2

Angiotensin-IV is primarily produced from angiotensin-III by the removal of an arginine residue from the N-terminal by membrane alanyl aminopeptidase N (AP-N). Ang-IV can however also be formed by the action of aminopeptidases on Ang-I directly.Ang-IV has been shown to enhance cognitive functions, although how it does this in still unclear. It has been suggested that Ang-IV is able to inhibit the insulin-regulated aminopeptidase (IRAP) receptor in the brain (originally defined as the AT(4) receptor). IRAP is a single-spanning transmembrane zinc-metallopeptidase that belongs to the M1 family of aminopeptidases and its substrates include vasopressin, somatostatin, and cholecystokinin. The half-life of these compounds are prolonged when IRAP is inhibited by Ang-IV, and this may result in the enhanced cognitive abilities seen with Ang-IV treatment. c-Met, a tyrosine kinase receptor that binds hepatocyte growth factor (HGF) has also been proposed as an Ang IV targets. c-Met is associated with memory and learning consolidation.

Molecular weight: 774.4 g/mol

Ref: 3D-CRB1000686

Angiotensin IV trifluoroacetate

CAS: 12676-15-2

Angiotensin IV trifluoroacetate is an active analogue of angiotensin. It has been shown to have a high affinity for AT1 receptors and is able to enhance the uptake of angiotensin in proximal tubules, which may be due to its ability to bind DNA. Angiotensin IV trifluoroacetate has also been shown to have beneficial effects on skin cells, such as the reduction of skin inflammation and alleviation of pain. Angiotensin IV trifluoroacetate has shown anti-inflammatory activities, which may be due to its ability to reduce pro-inflammatory cytokines such as IL-6 and TNF-α. This drug also binds to the CD4 receptor, thereby inhibiting inflammatory responses in autoimmune diseases.Mass spectrometry of peptides and proteins using digestion by a grape cysteine protease at pH 3Z Perutka, M Å ebela - Journal of mass spectrometry, 2020 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jms.4444Integrating computational modeling and experimental assay to discover new potent ACE-inhibitory peptidesY Ren, Q Wang, S Chen, H Cao - Molecular Informatics, 2014 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/minf.201300131Absorption of casein antihypertensive peptides through an in vitro model of intestinal epitheliumM del Mar Contreras , AI Sancho , I Recio, C Mills - Food Digestion, 2012 - Springerhttps://link.springer.com/article/10.1007/s13228-012-0020-2Enhanced recombinant expression and purification of human IRAP for biochemical and crystallography studiesL Sui , HC Guo - Biochemistry and Biophysics Reports, 2021 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S2405580821001369The specific isolation of C-terminal peptides of proteins through a transamination reaction and its advantage for introducing functional groups into the peptideK Sonomura, H Kuyama , E Matsuo - Journal Devoted to , 2009 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/rcm.3920Fragmentation mechanisms of oxidized peptides elucidated by SID, RRKM modeling, and molecular dynamicsJM Spraggins , JA Lloyd, MV Johnston , J Laskin - Journal of the American , 2009 - Springerhttps://link.springer.com/article/10.1016/j.jasms.2009.04.012Gold ion-angiotensin peptide interaction by mass spectrometryJ Lee, LP Jayathilaka, S Gupta - Journal of the , 2012 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1007/s13361-011-0328-0Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidaseJ Lee , T Mustafa, SG McDowall - of Pharmacology and , 2003 - ASPEThttps://jpet.aspetjournals.org/content/305/1/205.shortA mechanistic investigation of the enhanced cleavage at histidine in the gas-phase dissociation of protonated peptidesG Tsaprailis, H Nair, W Zhong , K Kuppannan - Analytical , 2004 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ac034971jStudy of secondary specificity of enteropeptidase in comparison with trypsinAG Mikhailova, VV Likhareva, BV Vaskovsky - Biochemistry , 2004 - Springerhttps://link.springer.com/article/10.1023/B:BIRY.0000040224.47278.3b

Formula: C₄₀H₅₄N₈O₈•(C₂HF₃O₂)x

Purity: Min. 95%

Molecular weight: 774.9 g/mol

Ref: 3D-MAA67615