CAS 1267657-68-0
:[2H3]-Quinidine
Description:
[2H3]-Quinidine is a deuterated form of quinidine, an alkaloid derived from the bark of the cinchona tree, primarily used as an antiarrhythmic agent. The deuteration indicates that three hydrogen atoms in the quinidine molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the compound's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in studies involving drug metabolism and interactions. Quinidine itself is known for its ability to block sodium channels and has been employed in the treatment of various cardiac arrhythmias. The presence of deuterium can also aid in tracing studies and improve the understanding of the drug's behavior in biological systems. As with other quinidine derivatives, [2H3]-quinidine may exhibit similar therapeutic effects but could differ in its metabolic pathways and half-life due to the isotopic substitution. Safety and efficacy profiles would need to be evaluated in clinical settings, as with any pharmaceutical compound.
Formula:C20H24N2O2
Synonyms:- [2H3]-Quinidine
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Found 3 products.
Quinidine-d3
CAS:Controlled Product<p>Applications A dextrorotatory stereoizomer of Quinine. Antiarrhythmic (class IA). Antimalarial.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 483 (1983), Mason, J. W., et al.: Ann. N. Y. Acad. Sci., 432, 162 (1984),<br></p>Formula:C202H3H21N2O2Color and Shape:Off-WhiteMolecular weight:327.44Quinidine-d3
CAS:Controlled Product<p>Quinidine-d3 is an extracellular form of the drug quinidine. It has been shown to be a p-gp substrate and increases the concentration–time curve of the drug lenalidomide. Quinidine-d3 is also used to measure the pharmacokinetics of drugs in animals, specifically in CD-1 mice. The molecule quinidine was first isolated from cinchona bark and was later synthesized in 1874 by Adolph Strecker. Quinine is a derivative of quinidine that is used as an anti-malarial drug. There are potential drug interactions with quinidine because it inhibits CYP2D6, CYP2C9, CYP3A4, and CYP2C19 enzymes.</p>Formula:C20H21D3N2O2Purity:Min. 95%Molecular weight:327.44 g/mol
