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CAS 12684-33-2

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Sibiromycin

Description:
Sibiromycin is a macrolide antibiotic produced by the fermentation of certain strains of Streptomyces bacteria. It exhibits antibacterial properties, primarily targeting Gram-positive bacteria, and is known for its effectiveness against various infections. The chemical structure of sibiromycin features a large lactone ring, which is characteristic of macrolides, along with several sugar moieties that enhance its biological activity. Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing the elongation of peptide chains. Sibiromycin is often studied for its potential therapeutic applications, particularly in treating resistant bacterial strains. Additionally, it may have implications in research related to antibiotic development and resistance mechanisms. As with many antibiotics, the use of sibiromycin must be carefully managed to prevent the development of resistance, and its safety profile should be evaluated in clinical contexts. Overall, sibiromycin represents an important compound in the field of antimicrobial research and development.
Formula:C24H33N3O7
InChI:InChI=1S/C24H33N3O7/c1-6-7-13-8-15-21(30)26-17-14(22(31)27(15)10-13)9-16(11(2)18(17)28)34-23-20(29)24(4,32)19(25-5)12(3)33-23/h6-7,9-10,12,15,19-21,23,25-26,28-30,32H,8H2,1-5H3/b7-6+/t12-,15-,19-,20-,21+,23-,24+/m0/s1
InChI key:InChIKey=RAGFPHFDFVNLCG-INYQBOQCSA-N
SMILES:O=C1C=2C(N[C@H](O)[C@]3(N1C=C(/C=C/C)C3)[H])=C(O)C(C)=C(O[C@H]4[C@H](O)[C@](C)(O)[C@@H](NC)[C@H](C)O4)C2
Synonyms:
  • 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 7-[[4,6-dideoxy-3-C-methyl-4-(methylamino)-α-L-mannopyranosyl]oxy]-1,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-2-(1-propenyl)-, [11R-[2(E),11α,11aβ]]-
  • (11R,11aS)-7-[[4,6-Dideoxy-3-C-methyl-4-(methylamino)-α-L-mannopyranosyl]oxy]-1,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-2-(1E)-1-propen-1-yl-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
  • 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 7-[[4,6-dideoxy-3-C-methyl-4-(methylamino)-α-L-mannopyranosyl]oxy]-1,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-2-(1E)-1-propen-1-yl-, (11R,11aS)-
  • 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 7-[[4,6-dideoxy-3-C-methyl-4-(methylamino)-α-L-mannopyranosyl]oxy]-1,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-2-(1E)-1-propenyl-, (11R,11aS)-
  • Sibiromycin
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