CAS 126880-86-2

L-Selectin, also known as leukocyte selectin, is a type of cell adhesion molecule that plays a crucial role in the immune response by mediating the adhesion of leukocytes (white blood cells) to endothelial cells during inflammation. It is a glycoprotein that is primarily expressed on the surface of leukocytes, particularly lymphocytes and neutrophils. L-Selectin facilitates the rolling of these cells along the vascular endothelium, which is an essential step for their migration to sites of inflammation or injury. Structurally, L-Selectin consists of a lectin domain, an epidermal growth factor (EGF)-like domain, and a short cytoplasmic tail, which are important for its function and interaction with specific carbohydrate ligands on endothelial cells. The regulation of L-Selectin expression and its interactions are critical for proper immune function and can be influenced by various cytokines and chemokines. Dysregulation of L-Selectin has been implicated in various inflammatory diseases and conditions, making it a potential target for therapeutic interventions.