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CAS 126883-99-6

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Norverapamil N-b-D-Glucuronide

Description:
Norverapamil N-b-D-Glucuronide is a chemical compound that serves as a metabolite of the calcium channel blocker verapamil. It is characterized by its glucuronide conjugate structure, which is formed through the process of glucuronidation, a common phase II metabolic reaction that enhances the solubility and excretion of lipophilic drugs. This compound typically exhibits properties associated with its parent drug, such as potential cardiovascular effects, but with altered pharmacokinetics and pharmacodynamics due to the glucuronidation process. Norverapamil N-b-D-Glucuronide is generally more polar than verapamil, which may influence its distribution and elimination in biological systems. The compound is of interest in pharmacology and toxicology, particularly in understanding drug metabolism and the implications of drug interactions. Its CAS number, 126883-99-6, allows for precise identification in chemical databases and literature. Overall, Norverapamil N-b-D-Glucuronide plays a significant role in the metabolic pathway of verapamil, contributing to the overall therapeutic and side effect profile of the drug.
Formula:C32H44N2O10
InChI:InChI=1/C32H44N2O10/c1-19(2)32(18-33,21-9-11-23(41-4)25(17-21)43-6)13-7-14-34(15-12-20-8-10-22(40-3)24(16-20)42-5)30-28(37)26(35)27(36)29(44-30)31(38)39/h8-11,16-17,19,26-30,35-37H,7,12-15H2,1-6H3,(H,38,39)/t26?,27-,28?,29?,30+,32?/m1/s1
Synonyms:
  • 1-[[4-Cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl][2-(3,4-dimethoxyphenyl)ethyl]amino]-1-deoxy-b-D-glucopyranuronic Aci
  • 1-[[4-Cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl][2-(3,4-dimethoxyphenyl)ethyl]amino]-1-deoxy--D-glucopyranuronic Acid
  • Norverapamil N--D-Glucuronide
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