CAS 1268881-20-4

(4aS,5aS)-4,4a,5,5a-Tetrahydro-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-1-(4-oxido-2-pyrazinyl)-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide

Description:

The chemical substance with the name "(4aS,5aS)-4,4a,5,5a-Tetrahydro-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-1-(4-oxido-2-pyrazinyl)-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide" and CAS number "1268881-20-4" is a complex organic compound characterized by its unique structural features, including a cyclopropane and pyrazole moiety. This compound exhibits chirality, indicated by the presence of specific stereocenters, which can influence its biological activity and interactions. The presence of functional groups such as carboxamide and hydroxymethyl suggests potential for hydrogen bonding and reactivity, making it of interest in medicinal chemistry. Its intricate structure may contribute to specific pharmacological properties, potentially impacting its efficacy and safety profile in therapeutic applications. Additionally, the compound's solubility, stability, and reactivity would be influenced by its molecular architecture, which is essential for understanding its behavior in biological systems and during synthesis. Overall, this substance represents a significant area of study in drug development and chemical research.

Formula: C₁₈H₂₃N₅O₃

InChI: InChI=1S/C18H23N5O3/c1-18(2,3)13(9-24)20-17(25)15-12-7-10-6-11(10)16(12)23(21-15)14-8-22(26)5-4-19-14/h4-5,8,10-11,13,24H,6-7,9H2,1-3H3,(H,20,25)/t10-,11-,13+/m0/s1

InChI key: InChIKey=ACSQLTBPYZSGBA-GMXVVIOVSA-N

SMILES: C(N[C@@H](C(C)(C)C)CO)(=O)C=1C2=C([C@@]3([C@@](C3)(C2)[H])[H])N(N1)C=4C=N(=O)C=CN4

Synonyms:

• Olorinab
• (1aS,5aS)-2-(4-Oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide
• (4aS,5aS)-4,4a,5,5a-Tetrahydro-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-1-(4-oxido-2-pyrazinyl)-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide
• 1H-Cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide, 4,4a,5,5a-tetrahydro-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-1-(4-oxido-2-pyrazinyl)-, (4aS,5aS)-
• APD 371

APD 371 - Bio-X

CAS: 1268881-20-4

Formula: C₁₈H₂₃N₅O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 357.4069

Ref: IN-DA01EAUC

Olorinab

CAS: 1268881-20-4

Olorinab

Purity: ≥95%

Molecular weight: 357.41g/mol

Ref: 54-BUP01504

APD 371

CAS: 1268881-20-4

A selective cannabinoid receptor type 2 (CB2) agonist. Commonly, CB2 agonists induce receptor internalization, which results in desensitization and tachyphylaxis. However, APD 371 mediates efficient recycling of internalized receptors back to the plasma membrane and thus sustains analgesic effects, upon subchronic treatment, in an osteoarthritis pain model in vivo.

Formula: C₁₈H₂₃N₅O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 357.41 g/mol

Ref: 3D-BA165146

Olorinab

CAS: 1268881-20-4

Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.

Formula: C₁₈H₂₃N₅O₃

Purity: 97.67% - 98.47%

Color and Shape: Solid

Molecular weight: 357.41

Ref: TM-T14302