CAS 127-07-1

Hydroxyurea

Description:

Hydroxyurea, with the CAS number 127-07-1, is a chemical compound that serves as an antineoplastic agent, primarily used in the treatment of certain cancers, such as chronic myeloid leukemia and head and neck cancers, as well as in managing sickle cell disease. It is a white, crystalline solid that is soluble in water and exhibits a molecular formula of C₄H₈N₂O₂. Hydroxyurea functions as a ribonucleotide reductase inhibitor, which disrupts DNA synthesis by preventing the conversion of ribonucleotides to deoxyribonucleotides, thereby inhibiting cell proliferation. The compound is also known for its ability to increase fetal hemoglobin levels in patients with sickle cell disease, which can reduce the frequency of painful crises. Hydroxyurea is typically administered orally and may have side effects, including myelosuppression, gastrointestinal disturbances, and potential teratogenic effects, necessitating careful monitoring during treatment. Its mechanism of action and therapeutic applications make it a significant agent in oncology and hematology.

Formula: CH₄N₂O₂

InChI: InChI=1/CH4N2O2/c2-1(4)3-5/h3H2,(H2,2,4)

InChI key: InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N

SMILES: C(NO)(N)=O

Synonyms:

• 1-Hydroxyurea
• Amino(Oxido-Λ5-Azanyl)Methanone
• Biosupressin
• Carbamohydroxamic acid
• Carbamohydroximic acid
• Carbamoyl oxime
• Carbamyl hydroxamate
• Cytodrox
• Droxia
• HU
• Hidrix
• Hidroxicarbamida
• Hydrea
• Hydreia
• Hydrixycarbamide
• Hydroxy Urea (D4)
• Hydroxy urea
• Hydroxycarbamid
• Hydroxycarbamide
• Hydroxycarbamine
• Hydroxylamine, N-(aminocarbonyl)-
• Hydroxylurea
• Hydura
• Hydurea
• Litaler
• Litalir
• Mylocel
• N-(aminocarbonyl)hydroxylamine
• N-Carbamoylhydroxylamine
• N-Hydroxyharnstoff
• N-Hydroxyurea
• Nci C04831
• Nsc 32065
• Onco-carbide
• Oxyrea
• Oxyurea
• Siklos
• Sk 22591
• Sq 1089
• Urea, N-hydroxy-
• Urea, hydroxy-
• Wr 83799
• Xromi
• hydroxyharnstoff
• carbamylhydroxamate
• Carbamoylhydroxylamine
• carbamohydroxyamicacid
• carbamohydroxamicacid
• hydroxy-ure
• HYDROXYUREA
• carbamoyloxime

Hydroxyurea

CAS: 127-07-1

Formula: CH₄N₂O₂

Purity: >97.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 76.06

Ref: 3B-H0310

Hydroxyurea, 98%

CAS: 127-07-1

Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia

Formula: CH₄N₂O₂

Purity: 98%

Color and Shape: White to cream or yellow, Crystals or powder or crystalline powder

Molecular weight: 76.06

Ref: 02-A10831

HYDROXYCARBAMIDE CRS

CAS: 127-07-1

HYDROXYCARBAMIDE CRS

Formula: CH₄N₂O₂

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 76.0547

Ref: 41-Y0000119

Hydroxycarbamide

CAS: 127-07-1

Hydroxycarbamide

Formula: CH₄N₂O₂

Purity: 99.6%

Color and Shape: Off-White

Molecular weight: 76.02728

Ref: 47-197

Hydroxyurea

CAS: 127-07-1

Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugs

Formula: CH₄N₂O₂

Color and Shape: White Off-White Powder

Molecular weight: 76.06 g/mol

Ref: 45-1332000

Urea, N-hydroxy-

CAS: 127-07-1

Formula: CH₄N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 76.0547

Ref: IN-DA000WIJ

Hydroxyurea

CAS: 127-07-1

Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

Formula: CH₄N₂O₂

Purity: 99.85% - 99.92%

Color and Shape: Solid

Molecular weight: 76.05

Ref: TM-T0676

Hydroxyurea

CAS: 127-07-1

Formula: CH₄N₂O₂

Purity: 98.0 - 102.0 % (anhydrous basis)

Color and Shape: White to off-white powder

Molecular weight: 76.06

Ref: 7W-GP0795

Hydroxyurea

CAS: 127-07-1

Hydroxyurea

Purity: ≥98%

Molecular weight: 76.05g/mol

Ref: 54-BUP18378

Hydroxy Urea

CAS: 127-07-1

Formula: CH₄N₂O₂

Molecular weight: 76.06

Ref: 4Z-U-061

Hydroxyurea

CAS: 127-07-1

Hydroxyurea

Formula: CH₄N₂O₂

Purity: 98%

Color and Shape: white solid

Molecular weight: 76.05g/mol

Ref: 54-BIH0153

1-Hydroxyurea

CAS: 127-07-1

1-Hydroxyurea

Purity: 98%

Molecular weight: 76.05g/mol

Ref: 54-OR9108

Hydroxy Urea

Controlled Product

CAS: 127-07-1

Stability Hygroscopic
Applications An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.
References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),

Formula: CH₄N₂O₂

Color and Shape: White Solid

Molecular weight: 76.05

Ref: TR-H991000

Hydroxy Urea

CAS: 127-07-1

Formula: CH₄N₂O₂

Molecular weight: 76.06

Ref: ST-EA-CP-F32011

Hydroxyurea

CAS: 127-07-1

Hydroxyurea is a prodrug that is activated by the enzyme Jak2, which is found in the mitochondria of cells. Hydroxyurea is used to treat various types of cancer and other diseases, such as sickle cell anemia. It has been shown to be effective in inhibiting the growth of squamous cell carcinomas and myeloid leukemia cells. Hydroxyurea has also been shown to have synergistic effects when combined with other pharmacological agents, such as hydroxycarbamide and cytosine arabinoside. Hydroxyurea inhibits the production of energy in the form of ATP, which leads to death by apoptosis or necrosis. This drug also has inhibitory properties against bacterial infections, especially those caused by Mycobacterium tuberculosis and Mycobacterium avium complex.

Formula: CH₄N₂O₂

Purity: Min. 97.5 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 76.06 g/mol

Ref: 3D-FH09735

Hydroxyurea

CAS: 127-07-1

Formula: CH₄N₂O₂

Purity: 98%

Color and Shape: Solid, White crystalline powder

Molecular weight: 76.055

Ref: 10-F043351