CAS 127-31-1

Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-

Description:

Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-, commonly known as fludrocortisone, is a synthetic corticosteroid with potent mineralocorticoid properties. It is characterized by its fluorinated structure, which enhances its biological activity and stability. This compound is primarily used in the treatment of conditions such as adrenal insufficiency and orthostatic hypotension, where it helps to regulate electrolyte balance and blood pressure. Fludrocortisone acts by binding to mineralocorticoid receptors, promoting sodium retention and potassium excretion in the kidneys. Its pharmacological effects include increased blood volume and blood pressure, making it crucial in managing certain endocrine disorders. The compound is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in clinical settings. As with other corticosteroids, it may have side effects, including fluid retention, hypertension, and electrolyte imbalances, necessitating careful monitoring during treatment. Overall, fludrocortisone is an important therapeutic agent in endocrinology and is recognized for its efficacy in managing specific health conditions.

Formula: C₂₁H₂₇FO₅

InChI: InChI=1/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16?,17?,18-,20-,21-,22-,23-/m0/s1

InChI key: InChIKey=AAXVEMMRQDVLJB-BULBTXNYSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)CC3)[H])(CCC=4[C@]2(C)CCC(=O)C4)[H]

Synonyms:

• (11β)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
• 9-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione
• 9-Fluorocortisol
• 9-Fluorohydrocortisone
• 9α-Fludrocortisone
• 9α-Fluorcortisol
• 9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione
• 9α-Fluoro-17-hydroxycorticosterone
• 9α-Fluorocortisol
• 9α-Fluorohydrocortisone
• Alflorone
• Astonin-H
• F-Col
• F-Cortef
• Florinef
• Fludrocortison
• Fludrocortisona
• Fludrocortisone
• Fludrocortone
• Fludrone
• Fludronef
• Fluodrocortisone
• Fluohydrisone
• Fluohydrocortisone
• Fluorocortisol
• Fluorocortisone
• Fluorohydrocortisone
• Nsc 11318
• Pregn-4-ene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-
• 9-fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
• (11beta)-9-fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
• (8xi,11beta,14xi)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
• 9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregn-4-ene-3,20-dione
• Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-
• 9-fluoro-11-beta,17,21-trihydroxy-pregn-4-ene-20-dione
• 4-PREGNENE-9-ALPHA-FLUORO-11-BETA,17-ALPHA,21-TRIOL-3,20-DIONE
• 9-alpha-fluoro-17-hydroxycorticosterone
• 9alpha-fludrocortisone
• 9-ALPHA-FLUOROHYDROCORTISONE
• 9alpha-fluorocortisol
• 9-fluoro-11beta,17,21-trihydroxy-pregn-4-ene-20-dione
• 9-ALPHA-FLUORO-11-BETA,17-ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE
• 9alpha-fluoro-17-hydroxycorticosterone
• 9-alpha-fluorocortisol
• 9-fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione
• 4-PREGNEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE
• 17,21-trihydroxy-20-dion(11beta)-pregn-4-ene-9-fluoro-11

Fludrocortisone

CAS: 127-31-1

Formula: C₂₁H₂₉FO₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 380.4504

Ref: IN-DA007OWF

Fludrocortisone-d5

CAS: 127-31-1

Formula: C₂₁H₂₄D₅FO₅

Color and Shape: White To Off-White Solid

Molecular weight: 385.49

Ref: 4Z-F-116004

Fludrocortisone

CAS: 127-31-1

Fludrocortisone

Purity: ≥98%

Molecular weight: 380.45g/mol

Ref: 54-BUP05151

Fludrocortisone

CAS: 127-31-1

Fludrocortisone

Purity: 97%

Molecular weight: 380.4g/mol

Ref: 54-PC108627

Fludrocortisone

CAS: 127-31-1

Formula: C₂₁H₂₉FO₅

Color and Shape: Off-White Solid

Molecular weight: 380.46

Ref: 4Z-F-116001

Fludrocortisone-21,21-d2

CAS: 127-31-1

Purity: 95 atom % D

Color and Shape: White Solid

Molecular weight: 382.47

Ref: 3U-D6008

Fludrocortisone-d5 (Major)

Controlled Product

CAS: 127-31-1

Formula: C₂₁H₂₄D₅FO₅

Color and Shape: White Solid

Molecular weight: 385.48

Ref: TR-F428102

Fludrocortisone

Controlled Product

CAS: 127-31-1

Formula: C₂₁H₂₉FO₅

Color and Shape: White Solid

Molecular weight: 380.45

Ref: TR-F428100

Fludrocortisone

Controlled Product

CAS: 127-31-1

Fludrocortisone is a corticosteroid that is used to treat a variety of disorders, such as bowel disease, eye disorders and inflammatory diseases. Fludrocortisone can be administered orally or intravenously. Fludrocortisone has been shown to have a number of effects on the human body, including decreasing the size of inflamed tissue and inhibiting the production of prostaglandins. In addition, fludrocortisone has been shown to decrease the activity of leukocytes, which are white blood cells that fight against infection. Fludrocortisone also decreases the production of mucus in respiratory passages and reduces inflammation in various parts of the body.

Formula: C₂₁H₂₉FO₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 380.45 g/mol

Ref: 3D-FF23321

Fludrocortisone

CAS: 127-31-1

Fludrocortisone （Florinef） is a synthetic corticosteroid with moderate glucocorticoid potency and greater mineralocorticoid potency.Cost-effective and quality-assured.

Formula: C₂₁H₂₉FO₅

Purity: 98.56% - 98.66%

Color and Shape: White Solid

Molecular weight: 380.45

Ref: TM-T1666L