CAS 127-35-5

Phenazocine

Description:

Phenazocine is a synthetic opioid analgesic that exhibits potent analgesic properties, making it useful in pain management. It is classified as a member of the phenanthrene family and is structurally related to morphine. Phenazocine acts primarily as a mu-opioid receptor agonist, which contributes to its effectiveness in alleviating pain. However, it also has antagonist properties at kappa-opioid receptors, which can influence its overall pharmacological profile and side effects. The substance is typically administered via injection and has a relatively high potency compared to other opioids. Its side effects may include respiratory depression, sedation, and potential for dependence, similar to other opioids. Due to its potential for abuse and addiction, phenazocine is regulated in many countries. Additionally, its use has declined in favor of other analgesics that may have a more favorable safety profile. Overall, phenazocine is a significant compound in the context of opioid pharmacology, with specific characteristics that define its therapeutic and safety considerations.

Formula: C₂₂H₂₇NO

InChI: InChI=1S/C22H27NO/c1-16-21-14-18-8-9-19(24)15-20(18)22(16,2)11-13-23(21)12-10-17-6-4-3-5-7-17/h3-9,15-16,21,24H,10-14H2,1-2H3

InChI key: InChIKey=ZQHYKVKNPWDQSL-UHFFFAOYSA-N

SMILES: CC12C=3C(CC(C1C)N(CCC4=CC=CC=C4)CC2)=CC=C(O)C3

Synonyms:

• (2R,6R,11R)-6,11-dimethyl-3-(2-phenylethyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol
• 1,2,3,4,5,6-Hexahydro-6,11-Dimethyl-3-Phenethyl-2,6-Methano-3-Benzazocin-8-Ol
• 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-phenylethyl)-2,6-methano-3-benzazocin-8-ol
• 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(2-phenylethyl)-
• 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-phenethyl-
• 2′-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan
• 6,11-Dimethyl-3-(2-Phenylethyl)-1,2,3,4,5,6-Hexahydro-2,6-Methano-3-Benzazocin-8-Ol
• Phenethylazocine
• Phenobenzorphan
• Phenazocine

Phenazocine

Controlled Product

CAS: 127-35-5

Applications Phenazocine is an opioid analgesic drug related to Pentazocine (P274300) and has a similar profile of effects. The use of Phenazocine results in analgesia and euphoria and in some cases dysphoria and hallucinations at high doses, most likely due to action at κ-opioid and σ receptors. Phenazocine is a much more potent analgesic than morphine with about 4 times the potency and very little side effects making it a better treatment option for biliary or pancreatic pain.Controlled Substance.
References Hopton, D., et al.: Gut, 12, 51 (1971); Eckenhoff, J.E., et al.: Anesthesiology, 20, 355 (1959); Clarke, E.G., et al.: Nature, 184, 451 (1959);

Formula: C₂₂H₂₇NO

Color and Shape: Neat

Molecular weight: 321.46

Ref: TR-P295400