CAS 12707-58-3: Ganglioside GD1a
Description:Ganglioside GD1a is a complex glycosphingolipid primarily found in the nervous system, particularly in the membranes of neurons. It is characterized by its structure, which includes a ceramide backbone linked to a carbohydrate moiety that contains sialic acid, specifically N-acetylneuraminic acid. This structure contributes to its role in cell signaling, cell recognition, and modulation of neuronal activity. GD1a is known to participate in various biological processes, including neurodevelopment and synaptic plasticity. It is also implicated in certain pathological conditions, such as neurodegenerative diseases. The presence of sialic acid in its structure gives GD1a a negative charge, influencing its interactions with other biomolecules. Additionally, gangliosides like GD1a are involved in the formation of lipid rafts, which are microdomains in cell membranes that play critical roles in signal transduction. Overall, GD1a is an important component of neuronal membranes, contributing to both structural integrity and functional dynamics within the nervous system.
Formula:Unspecified
InChI:InChI=1/C86H152N4O39.2Na/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-51(100)50(90-60(105)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2)46-118-80-69(111)67(109)72(57(43-94)120-80)123-82-71(113)78(129-86(84(116)117)39-53(102)62(88-48(4)98)77(128-86)65(107)55(104)41-92)74(59(45-96)122-82)124-79-63(89-49(5)99)75(66(108)56(42-93)119-79)125-81-70(112)68(110)73(58(44-95)121-81)126-85(83(114)115)38-52(101)61(87-47(3)97)76(127-85)64(106)54(103)40-91;;/h34,36,50-59,61-82,91-96,100-104,106-113H,6-33,35,37-46H2,1-5H3,(H,87,97)(H,88,98)(H,89,99)(H,90,105)(H,114,115)(H,116,117);;/q;2*+1/p-2/b36-34+;;/t50-,51+,52?,53?,54-,55-,56?,57?,58?,59?,61+,62+,63?,64-,65-,66?,67?,68?,69?,70?,71?,72?,73?,74?,75?,76?,77?,78?,79?,80?,81?,82?,85?,86?;;/m0../s1
- Synonyms:
- G<sub>D1a</sub>
- GD1a
- Ganglioside B1
- Ganglioside B<sub>1</sub>
- Ganglioside G3
- Ganglioside G<sub>3</sub>
- Ganglioside G<sub>D1a</sub>
- Ganglioside G<sub>II</sub>
- Ganglioside GD1a
- Ganglioside GII
- See more synonyms
- disialoganglioside-gd1A from bovine*brain
