CAS 127228-54-0

L-Glutamic acid,N-[[5-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-2-thienyl]carbonyl]-

Description:

L-Glutamic acid, N-[[5-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-2-thienyl]carbonyl]- is a complex organic compound characterized by its amino acid backbone, specifically L-glutamic acid, which is known for its role as a neurotransmitter in the central nervous system. The compound features a thienyl group and a pyrido-pyrimidine structure, indicating potential biological activity and interaction with various receptors. Its molecular structure suggests it may exhibit properties such as solubility in polar solvents and the ability to form hydrogen bonds due to the presence of amino and carboxyl functional groups. The compound's specific stereochemistry, particularly the (6R) configuration, may influence its pharmacological properties and interactions with biological targets. As a result, it may have applications in medicinal chemistry, potentially serving as a lead compound for drug development or as a biochemical probe in research settings. Further studies would be necessary to elucidate its full range of characteristics and potential uses.

Formula: C₁₉H₂₃N₅O₆S

Synonyms:

• L-Glutamicacid, N-[[5-[2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl]-2-thienyl]carbonyl]-,(R)-
• L-Glutamic acid,N-[[5-[2-[(6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-2-thienyl]carbonyl]-(9CI)
• Pyrido[2,3-d]pyrimidine, L-glutamic acid deriv.
• Garft II
• Ly 309887

LY 309887

CAS: 127228-54-0

LY 309887 is a synthetic analog of the natural compound LY315920. It has significant cytotoxicity in prostate cancer cells and leukemia cells. LY 309887 also inhibits cell growth in l1210 murine cells by blocking the ATP synthesis, which is required for cell division. It may also be effective against autoimmune diseases due to its ability to inhibit macrophage inflammatory activity and decrease tumor xenografts. The biochemical mechanism of action for LY 309887 is unknown at this time.

Formula: C₁₉H₂₃N₅O₆S

Purity: Min. 95%

Molecular weight: 449.5 g/mol

Ref: 3D-CFA22854

LY309887

CAS: 127228-54-0

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.

Formula: C₁₉H₂₃N₅O₆S

Color and Shape: Solid

Molecular weight: 449.48

Ref: TM-T15813