CAS 127243-85-0: Protein kinase inhibitor H89

Description: Protein kinase inhibitor H89 is a synthetic compound primarily known for its role as a selective inhibitor of protein kinase A (PKA). It is characterized by its ability to interfere with the phosphorylation processes mediated by PKA, thereby influencing various cellular signaling pathways. H89 is often utilized in biochemical research to study the effects of PKA inhibition on cellular functions, including cell growth, differentiation, and apoptosis. The compound is typically soluble in organic solvents and exhibits moderate stability under physiological conditions. Its mechanism of action involves competitive inhibition, where H89 binds to the ATP-binding site of PKA, preventing ATP from activating the kinase. This inhibition can lead to downstream effects on various cellular processes, making H89 a valuable tool in pharmacological studies. Additionally, H89 has been investigated for its potential therapeutic applications in various diseases, including cancer and cardiovascular disorders, due to its ability to modulate signaling pathways. However, like many inhibitors, its specificity and potential off-target effects should be carefully considered in experimental designs.

Formula: C₂₀H₂₀BrN₃O₂S

InChI: InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2

InChI key: InChIKey=ZKZXNDJNWUTGDK-UHFFFAOYSA-N

SMILES: O=S(=O)(NCCNCC=CC1=CC=C(Br)C=C1)C2=CC=CC=3C=NC=CC32

Synonyms:

• 5-Isoquinolinesulfonamide, N-(2-((3-(4-bromophenyl)-2-propenyl)amino)ethyl)-
• 5-Isoquinolinesulfonamide, N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-
• H 89 (pharmaceutical)
• H-89
• H-89 Dihydrochloride Hydrate
• H-89 Hydrochloride
• H-89 hydrate dihydrochloride
• H89
• IQB
• N-(2-((3-(4-Bromophenyl)-2-propenyl)amino)ehtyl)-5-isoquinolinesulfonamide dihydrochloride
• N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide
• N-(2-[P-Bromocinnamylamino]Ethyl)-5-Isoquinolinesulfonamide Hydrochloride
• N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide
• N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide dihydrochloride
• N-[2-(4-Bromocinnamylamino)Ethyl]-5-Isoquinoline Sulfonamide
• N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE dihydrochloride
• N-[2-(P-Bromocinnamylamino)Ethyl]-5-Isoquinolinesulfonamide 2Hcl
• N-[2-[P-Bromocinnamylamino]-Ethyl]-5-Isoquinolinesulfonmide
• N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide
• N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide
• Protein kinase inhibitor H89

5-Isoquinolinesulfonamide, N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-

CAS: 127243-85-0

• Formula: C₂₀H₂₀BrN₃O₂S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 446.3607

H-89

CAS: 127243-85-0

• Molecular weight: 446.36g/mol

N-[2-(p-Bromocinnamylamino)Ethyl]-5-Isoquinolinesulfonamide Dihydrochloride

CAS: 127243-85-0

• Purity: 98%
• Molecular weight: 446.36g/mol

H-89

CAS: 127243-85-0

• Formula: C₂₀H₂₀BrN₃O₂S
• Purity: >98.0%(HPLC)(qNMR)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 446.36

H-89

CAS: 127243-85-0

H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and …

• Formula: C₂₀H₂₀BrN₃O₂S
• Purity: 98.06%
• Color and Shape: Off-White Powder
• Molecular weight: 446.36

N-[2-(p-Bromocinnamylamino)ethyl]-5-Isoquinoline Sulfonamide

CAS: 127243-85-0

• Formula: C₂₀H₂₀BrN₃O₂S
• Color and Shape: Neat
• Molecular weight: 446.36

H89

CAS: 127243-85-0

• Formula: C₂₀H₂₀BrN₃O₂S
• Color and Shape: Neat
• Molecular weight: 446.36

N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide

CAS: 127243-85-0

N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide (BQCA) is a potent inhibitor of protein kinase C. It has been shown …

• Formula: C₂₀H₂₀BrN₃O₂S
• Purity: Min. 95%
• Molecular weight: 446.36 g/mol