CAS 127243-85-0

Protein kinase inhibitor H89

Description:

Protein kinase inhibitor H89 is a synthetic compound primarily known for its role as a selective inhibitor of protein kinase A (PKA). It is characterized by its ability to interfere with the phosphorylation processes mediated by PKA, thereby influencing various cellular signaling pathways. H89 is often utilized in biochemical research to study the effects of PKA inhibition on cellular functions, including cell growth, differentiation, and apoptosis. The compound is typically soluble in organic solvents and exhibits moderate stability under physiological conditions. Its mechanism of action involves competitive inhibition, where H89 binds to the ATP-binding site of PKA, preventing ATP from activating the kinase. This inhibition can lead to downstream effects on various cellular processes, making H89 a valuable tool in pharmacological studies. Additionally, H89 has been investigated for its potential therapeutic applications in various diseases, including cancer and cardiovascular disorders, due to its ability to modulate signaling pathways. However, like many inhibitors, its specificity and potential off-target effects should be carefully considered in experimental designs.

Formula: C₂₀H₂₀BrN₃O₂S

InChI: InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2

InChI key: InChIKey=ZKZXNDJNWUTGDK-UHFFFAOYSA-N

SMILES: S(NCCNCC=CC1=CC=C(Br)C=C1)(=O)(=O)C=2C3=C(C=CC2)C=NC=C3

Synonyms:

• 5-Isoquinolinesulfonamide, N-(2-((3-(4-bromophenyl)-2-propenyl)amino)ethyl)-
• 5-Isoquinolinesulfonamide, N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-
• H 89 (pharmaceutical)
• H-89
• H-89 Dihydrochloride Hydrate
• H-89 Hydrochloride
• H-89 hydrate dihydrochloride
• H89
• IQB
• N-(2-((3-(4-Bromophenyl)-2-propenyl)amino)ehtyl)-5-isoquinolinesulfonamide dihydrochloride
• N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide
• N-(2-[P-Bromocinnamylamino]Ethyl)-5-Isoquinolinesulfonamide Hydrochloride
• N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide
• N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide dihydrochloride
• N-[2-(4-Bromocinnamylamino)Ethyl]-5-Isoquinoline Sulfonamide
• N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE dihydrochloride
• N-[2-(P-Bromocinnamylamino)Ethyl]-5-Isoquinolinesulfonamide 2Hcl
• N-[2-[P-Bromocinnamylamino]-Ethyl]-5-Isoquinolinesulfonmide
• N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide
• N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide

5-Isoquinolinesulfonamide, N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-

CAS: 127243-85-0

Formula: C₂₀H₂₀BrN₃O₂S

Purity: 97%

Color and Shape: Solid

Molecular weight: 446.3607

Ref: IN-DA000WT2

N-[2-(p-Bromocinnamylamino)Ethyl]-5-Isoquinolinesulfonamide Dihydrochloride

CAS: 127243-85-0

N-[2-(p-Bromocinnamylamino)Ethyl]-5-Isoquinolinesulfonamide Dihydrochloride

Purity: 98%

Molecular weight: 446.36g/mol

Ref: 54-OR1014169

H-89

CAS: 127243-85-0

H-89

Purity: ≥98%

Molecular weight: 446.36g/mol

Ref: 54-BUP10933

H-89

CAS: 127243-85-0

Formula: C₂₀H₂₀BrN₃O₂S

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 446.36

Ref: 3B-H1660

N-[2-(p-Bromocinnamylamino)ethyl]-5-Isoquinoline Sulfonamide

Controlled Product

CAS: 127243-85-0

Formula: C₂₀H₂₀BrN₃O₂S

Color and Shape: Neat

Molecular weight: 446.36

Ref: TR-B682440

H-89

CAS: 127243-85-0

H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.

Formula: C₂₀H₂₀BrN₃O₂S

Purity: 98.06%

Color and Shape: Off-White Powder

Molecular weight: 446.36

Ref: TM-T11524

H89

Controlled Product

CAS: 127243-85-0

Formula: C₂₀H₂₀BrN₃O₂S

Color and Shape: Neat

Molecular weight: 446.36

Ref: TR-H956473