CAS 127252-80-6

Clarithromycin EP Impurity O

CAS: 127252-80-6

Formula: C₃₉H₇₂N₂O₁₃

Color and Shape: White To Off-White Solid

Molecular weight: 777.01

Ref: 4Z-C-3715

Clarithromycin EP Impurity O

CAS: 127252-80-6

Formula: C₃₉H₇₂N₂O₁₃

Molecular weight: 777.01

Ref: ST-EA-CP-C1015

Clarithromycin (9Z)-O-Methyloxime

Controlled Product

CAS: 127252-80-6

Impurity Clarithromycin Impurity O EP
Stability Hygroscopic
Applications Clarithromycin (9Z)-O-Methyloxime is an impurity of Clarithromycin (C559750); a semi-synthetic macrolide antibiotic and derivative of Erythromycin (E650000).
References Morgan, D., et al.: J. Chromatogr., 502, 351 (1990); Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987); Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012); Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012)

Formula: C₃₉H₇₂N₂O₁₃

Color and Shape: Beige Solid

Molecular weight: 776.99

Ref: TR-C559775

Clarithromycin impurity O

CAS: 127252-80-6

Clarithromycin impurity O is a crystalline form of clarithromycin that is obtained by the sulfation of the free base. It is prepared by adding an acid binding agent to the free base and then dissolving it in water. The sulfate salt of clarithromycin impurity O can be purified by recrystallization. Clarithromycin impurity O has been used as a raw material for clarithromycin, which is a β-lactam antibiotic with activity against Gram-positive bacteria and some Gram-negative bacteria. Clarithromycin impurity O is also used in other pharmaceuticals such as anti-inflammatory drugs and antibiotics. The preparation process starts with the methylation reaction of potassium hydroxide, followed by hydrolysis to produce methyl sulfate and dimethyl sulfate. The methylated product is purified through distillation, vacuum drying, or crystallization, yielding a pure form of methylated product that can be further processed into other

Formula: C₃₉H₇₂N₂O₁₃

Purity: Min. 95%

Molecular weight: 776.99 g/mol

Ref: 3D-OC166153