CAS 127254-10-8

3-Quinolinecarboxylicacid,7-[(7R)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-

Description:

3-Quinolinecarboxylic acid, 7-[(7R)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- is a complex organic compound characterized by its quinoline and spirocyclic structures. This substance features a quinoline ring system, which is known for its aromatic properties and biological activity. The presence of a carboxylic acid functional group indicates potential acidity and reactivity, while the amino group contributes to its basicity and potential for forming hydrogen bonds. The compound also contains halogen substituents, specifically chlorine and fluorine, which can influence its lipophilicity and biological interactions. The spirocyclic structure adds to its three-dimensional complexity, potentially affecting its pharmacokinetics and binding affinity in biological systems. Overall, this compound may exhibit significant pharmacological properties, making it of interest in medicinal chemistry and drug development. However, specific biological activities and applications would require further investigation through experimental studies.

Formula: C₁₉H₁₈ClF₂N₃O₃

Synonyms:

• 3-Quinolinecarboxylicacid,7-(7-amino-5-azaspiro[2.4]hept-5-yl)-8-chloro-6-fluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-,[1R-[1a(R*),2a]]-
• 5-Azaspiro[2.4]heptane, 3-quinolinecarboxylicacid deriv.
• Du 6857

(1R,2S,7R)-Sitafloxacin HCl

CAS: 127254-10-8

Formula: C₁₉H₁₈ClF₂N₃O₃·HCl

Color and Shape: Yellow Solid

Molecular weight: 409.82 36.46

Ref: 4Z-S-079006

(1R,2S,7R)-Sitafloxacin-d4 HCl

CAS: 127254-10-8

Formula: C₁₉H₁₄ClF₂N₃O₃D₄·HCl

Color and Shape: Yellow Solid

Molecular weight: 413.85 36.46

Ref: 4Z-S-079007

DU 6857

CAS: 127254-10-8

DU 6857 is a potent, broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV. It has been shown to be effective against multidrug-resistant strains of bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis. DU 6857 binds to the enzyme DNA gyrase to inhibit the production of proteins vital for cell division. The drug has been shown to have no significant toxicity in humans in clinical trials. However, it should not be used in patients with hypersensitivity reactions or renal dysfunction due to its potential for adverse effects on the kidneys.

Formula: C₁₉H₁₈ClF₂N₃O₃

Purity: Min. 95%

Molecular weight: 409.8 g/mol

Ref: 3D-CFA25410

(1R,2S,7R)-Sitafloxacin

CAS: 127254-10-8

(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.

Formula: C₁₉H₁₈ClF₂N₃O₃

Color and Shape: Solid

Molecular weight: 409.814

Ref: TM-T206262