CAS 127308-82-1

Zamifenacin

Description:

Zamifenacin is a chemical compound classified as an antimuscarinic agent, primarily used for the treatment of overactive bladder and related urinary disorders. It functions by selectively blocking muscarinic receptors in the bladder, thereby reducing involuntary contractions and increasing bladder capacity. The compound is characterized by its ability to provide symptomatic relief from urinary urgency and frequency. Zamifenacin exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a relatively long half-life, which supports once-daily dosing. Its chemical structure includes specific functional groups that contribute to its receptor selectivity and therapeutic efficacy. Additionally, Zamifenacin is noted for having a lower incidence of side effects compared to some other antimuscarinics, making it a preferred option for many patients. As with any medication, the use of Zamifenacin should be guided by a healthcare professional, considering potential interactions and contraindications. Overall, its development represents a significant advancement in the management of urinary disorders.

Formula: C₂₇H₂₉NO₃

InChI: InChI=1S/C27H29NO3/c1-3-8-22(9-4-1)27(23-10-5-2-6-11-23)31-24-12-7-16-28(19-24)17-15-21-13-14-25-26(18-21)30-20-29-25/h1-6,8-11,13-14,18,24,27H,7,12,15-17,19-20H2/t24-/m1/s1

InChI key: InChIKey=BDNFQGRSKSQXRI-XMMPIXPASA-N

SMILES: C(O[C@H]1CN(CCC=2C=C3C(=CC2)OCO3)CCC1)(C4=CC=CC=C4)C5=CC=CC=C5

Synonyms:

• (+)-Zamifenacine
• (3R)-1-[2-(1,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidine
• 1-[2-(1,3-Benzodioxol-5-Yl)Ethyl]-3-(Diphenylmethoxy)Piperidine
• Piperidine, 1-[2-(1,3-benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)-, (3R)-
• Piperidine, 1-[2-(1,3-benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)-, (R)-
• Uk 76654
• Zamifenacin

Zamifenacin

CAS: 127308-82-1

Zamifenacin obviously decreases colonic motility in irritable bowel syndrome. Zamifenacin is an effective gut-selective muscarinic M3 receptor antagonist.

Formula: C₂₇H₂₉NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 415.52

Ref: TM-T17283

Zamifenacin

CAS: 127308-82-1

Zamifenacin is an activator of GABA receptors that blocks the flow of ions across nerve cell membranes. It is used in the treatment of overactive bladder and urinary incontinence. Zamifenacin is a potent inhibitor of ion channels, which are integral to the function of neurons and other cells in the body. Zamifenacin binds to specific regions on peptides called ligands, which are also found on ion channels. Zamifenacin has been shown to inhibit the binding of antibodies to receptor sites on cells, which may provide a possible mechanism for its anti-inflammatory effects.

Formula: C₂₇H₂₉NO₃

Purity: Min. 95%

Molecular weight: 415.5 g/mol

Ref: 3D-CFA30882