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CAS 127420-24-0

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Idrapril

Description:
Idrapril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It functions by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. The chemical structure of Idrapril includes a carboxylic acid group, which is essential for its biological activity. It is typically administered orally and is known for its relatively favorable side effect profile compared to other ACE inhibitors. Common side effects may include cough, hyperkalemia, and hypotension, although these are generally less pronounced. Idrapril is also notable for its prodrug nature, meaning it is metabolized in the body to its active form, which enhances its therapeutic efficacy. As with other medications in its class, it is contraindicated in pregnancy due to potential teratogenic effects. Overall, Idrapril represents a valuable option in the management of cardiovascular conditions, contributing to improved patient outcomes when used appropriately.
Formula:C11H18N2O5
InChI:InChI=1S/C11H18N2O5/c1-13(6-9(14)12-18)10(15)7-4-2-3-5-8(7)11(16)17/h7-8,18H,2-6H2,1H3,(H,12,14)(H,16,17)/t7-,8+/m1/s1
InChI key:InChIKey=QKIVRALZQSUWHH-SFYZADRCSA-N
SMILES:C(N(CC(NO)=O)C)(=O)[C@H]1[C@@H](C(O)=O)CCCC1
Synonyms:
  • Cyclohexanecarboxylic acid, 2-[[[2-(hydroxyamino)-2-oxoethyl]methylamino]carbonyl]-, (1S-cis)-
  • Cyclohexanecarboxylic acid, 2-[[[2-(hydroxyamino)-2-oxoethyl]methylamino]carbonyl]-, (1S,2R)-
  • Idrapril
  • (1S,2R)-2-[[[2-(Hydroxyamino)-2-oxoethyl]methylamino]carbonyl]cyclohexanecarboxylic acid
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