CAS 127464-60-2

Vascular endothelial growth factor

Description:

Vascular endothelial growth factor (VEGF) is a signaling protein that plays a crucial role in angiogenesis, the process of new blood vessel formation. It is primarily involved in the regulation of endothelial cell growth, migration, and survival. VEGF is produced by various cell types, including macrophages, platelets, and tumor cells, particularly in response to hypoxic conditions. The protein exists in several isoforms, which differ in their biological activity and receptor binding properties. VEGF exerts its effects by binding to specific receptors on endothelial cells, leading to a cascade of intracellular signaling that promotes vascular permeability and endothelial proliferation. It is also implicated in various physiological and pathological processes, including wound healing, inflammation, and tumor growth. Due to its significant role in cancer biology, VEGF has become a target for therapeutic interventions, with several anti-VEGF drugs developed for cancer treatment and other diseases characterized by abnormal blood vessel growth. Its CAS number, 127464-60-2, is used for identification in chemical databases and regulatory contexts.

Formula: Unspecified

Synonyms:

• Animal growth regulator, VEGF
• Animal growth regulators, VEGF
• Animal growth regulators, VEGF (vascular endothelial growth factor)
• Animal growth regulators, glioma-derived vascular endothelial growth factors
• Cytokines, vascular permeability factor
• FSdGF pituitary hormone
• FSdGF pituitary hormones
• Folliculo-stellate-derived growth factor
• Folliculo-stellate-derived growth factors
• FsDGF
• Gd-Vegf
• Glioma-derived vascular endothelial cell growth factor
• Glioma-derived vascular endothelial growth factors
• Pituitary hormones, folliculo-stellate-derived growth factors
• Sh-Polypeptide 9
• Vascular endothelial cell growth factor
• Vascular endothelial growth factor
• Vascular endothelial growth factors
• Vascular endotheolial growth factor
• Vascular permeability factor
• Vascular permeability factors