CAS 127472-42-8

GRANISETRON IMPURITY A

Description:

Granisetron Impurity A, with the CAS number 127472-42-8, is a chemical compound that is typically associated with the synthesis and quality control of granisetron, a medication used to prevent nausea and vomiting caused by chemotherapy or surgery. As an impurity, it may arise during the manufacturing process of granisetron and is important for analytical chemistry and pharmaceutical development. The characteristics of Granisetron Impurity A include its molecular structure, which is related to the parent compound, and its potential effects on the pharmacological profile of granisetron. It is essential to monitor such impurities to ensure the safety and efficacy of the final pharmaceutical product. The compound may exhibit specific solubility properties, stability under various conditions, and reactivity that can influence its behavior in formulations. Analytical techniques such as chromatography are often employed to identify and quantify impurities like Granisetron Impurity A in pharmaceutical preparations. Understanding these characteristics is crucial for regulatory compliance and maintaining the integrity of drug formulations.

Formula: C₁₈H₂₄N₄O

Synonyms:

• 1-Desmethyl 2-Methyl Granisetron (Granisetron Impurity A)
• endo-N-(9-Methyl-9-Azabicyclo[3.3.1]non-3-yl)-2-methyl-2H-indazole-3-carboxamide

GRANISETRON IMPURITY A CRS

CAS: 127472-42-8

GRANISETRON IMPURITY A CRS

Ref: 41-Y0000477

Granisetron Related Compound A (2-methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indazole-3-carboxamide)

CAS: 127472-42-8

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₈H₂₄N₄O

Color and Shape: White Off-White Powder

Molecular weight: 312.19501

Ref: 45-1298117

1-Desmethyl 2-Methyl Granisetron

CAS: 127472-42-8

Formula: C₁₈H₂₄N₄O

Color and Shape: Solid

Molecular weight: 312.4094

Ref: IN-DA000X4D

Granisetron EP Impurity A (Granisetron USP Related Compound A)

CAS: 127472-42-8

Formula: C₁₈H₂₄N₄O

Color and Shape: White To Off-White Solid

Molecular weight: 312.42

Ref: 4Z-G-0712

2-Methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indazole-3-carboxamide

CAS: 127472-42-8

Color and Shape: Neat

Ref: 86-MM0398.01

1-Desmethyl 2-Methyl Granisetron (Granisetron Impurity A)

CAS: 127472-42-8

Impurity Granisetron USP Related Compound A
Applications An impurity in the synthesis of Granisetron Hydrochloride. Granisetron Impurity A.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nishikawa, M., et al.: Drug Metab. Pharmacokin., 19, 280 (2004), Firkusny, L., et al.: Biochem. Pharmacol., 49, 1777 (1995), Sanwald, P., et al.: Drug Metab. Dispos., 24, 602 (1996), Vanderstreene, et al.: J. Labelled Comp. Radiopharm., XLI, 3, 71 (1997),

Formula: C₁₈H₂₄N₄O

Color and Shape: Light Yellow Solid

Molecular weight: 312.41

Ref: TR-D292085

1-Desmethyl 2-methyl granisetron

Controlled Product

CAS: 127472-42-8

Granisetron is a serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonist. It is used in the prevention and treatment of nausea and vomiting caused by cytotoxic chemotherapy, radiation therapy, or surgery. Granisetron hydrochloride is a white to off-white powder with a molecular weight of 476.0. The chemical formula for granisetron hydrochloride is C22H24ClN2O2S. This drug has been shown to be efficient in the prevention and treatment of nausea and vomiting caused by cytotoxic chemotherapy, radiation therapy, or surgery. The potential impurities are as follows:
1) 1-Desmethyl 2-methyl granisetron
2) 2-Methyl granisetron
3) 2-Methyl 3-(4'-hydroxyphenyl)propionitrile
4) 2-(4'-Hydroxyphenyl)-3-(

Formula: C₁₈H₂₄N₄O

Purity: Min. 95%

Molecular weight: 312.41 g/mol

Ref: 3D-ID21230

Granisetron EP Impurity A

CAS: 127472-42-8

Formula: C₁₈H₂₄N₄O

Molecular weight: 312.42

Ref: ST-EA-CP-G16001