CAS 127512-29-2

DODAP

Description:

DODAP, or dioctadecyldimethylammonium phosphate, is a quaternary ammonium compound characterized by its long hydrophobic alkyl chains and a positively charged ammonium group. It is typically used as a surfactant and emulsifying agent due to its amphiphilic nature, which allows it to interact with both hydrophilic and hydrophobic substances. DODAP is known for its ability to form stable lipid bilayers and is often utilized in the formulation of liposomes and other nanocarriers for drug delivery applications. Its structure contributes to its effectiveness in encapsulating hydrophobic drugs, enhancing their solubility and bioavailability. Additionally, DODAP exhibits biocompatibility, making it suitable for pharmaceutical and biomedical applications. However, like many quaternary ammonium compounds, it may also possess antimicrobial properties, which can be advantageous in certain formulations. Overall, DODAP's unique properties make it a valuable compound in various fields, including pharmaceuticals, cosmetics, and materials science.

Formula: C₄₁H₇₇NO₄

InChI: InChI=1/C41H77NO4/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-40(43)45-38-39(37-42(3)4)46-41(44)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,39H,5-18,23-38H2,1-4H3/b21-19-,22-20-

SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OCC(CN(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC

Synonyms:

• 18:1 Dap
• 1,2-Dioleoyloxy-3-(Dimethylamino)Propane
• 1,2-Dioleoyl-3-Dimethylammonium-Propane
• 3-(dimethylamino)propane-1,2-diyl (9Z,9'Z)bis-octadec-9-enoate

9-Octadecenoic acid (9Z)-, 1,1'-[1-[(dimethylamino)methyl]-1,2-ethanediyl] ester

CAS: 127512-29-2

Formula: C₄₁H₇₇NO₄

Purity: 98%

Color and Shape: Liquid

Molecular weight: 648.0544

Ref: IN-DA000X5P

1,2-Dioleoyl-3-Dimethylammonium-Propane

CAS: 127512-29-2

1,2-Dioleoyl-3-Dimethylammonium-Propane

Purity: 98%

Molecular weight: 648.05g/mol

Ref: 54-OR1030872

1,2-Dioleoyloxy-3-(dimethylamino)propane

CAS: 127512-29-2

Formula: C41H77NO4

Purity: >98%

Color and Shape: Solid

Molecular weight: 648.06

Ref: 48-16-1801

3-(Dimethylamino)propane-1,2-diyl Dioleate

CAS: 127512-29-2

Formula: C₄₁H₇₇NO₄

Purity: >95.0%(qNMR)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 648.07

Ref: 3B-D6266

DODAP

CAS: 127512-29-2

DODAP is an ionic cationic lipid high transfection efficiency that can be used to synthesize liposomes and encapsulate mRNA, siRNA and plasmid DNA.

Formula: C₄₁H₇₇NO₄

Purity: 98.7%

Color and Shape: Solid

Molecular weight: 648.05

Ref: TM-T38679

1,2-Dioleoyloxy-3-(dimethylamino)propane

Controlled Product

CAS: 127512-29-2

Applications Cationic amphiphiles are being studied for their potential role in preparing liposomes for interaction with artificial and biological membranes and cellular transfection techniques. Cationic species with ester linkages to the hydrophobic portion are more easily degraded by recipient cells and more efficiently metabolized.
References Leventis, R., and Silvus, J.R.: Biochimica et Biophysica Acta, 1023, 124 (1990)

Formula: C₄₁H₇₇NO₄

Color and Shape: Neat

Molecular weight: 648.05

Ref: TR-D483000