CAS 127634-20-2

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT

Description:

8-Bromoadenosine-3',5'-cyclic monophosphorothioate, SP-isomer sodium salt, with CAS number 127634-20-2, is a synthetic nucleotide analog that serves as a potent biochemical tool in research, particularly in studies involving cyclic nucleotide signaling pathways. This compound features a bromine atom at the 8-position of the adenosine moiety, which can influence its biological activity and receptor interactions. The cyclic monophosphate structure is crucial for mimicking the natural signaling molecules, such as cyclic AMP, and plays a significant role in cellular signaling processes. The phosphorothioate modification enhances its stability against enzymatic degradation, making it a valuable reagent in pharmacological and biochemical studies. As a sodium salt, it is typically soluble in aqueous solutions, facilitating its use in various experimental conditions. Researchers utilize this compound to investigate its effects on cellular processes, including signal transduction, gene expression, and enzyme activity, contributing to a deeper understanding of cellular mechanisms and potential therapeutic applications.

Formula: C₁₀H₁₁BrN₅O₅PS

Synonyms:

• Adenosine 3',5'-Cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt
• 8-Br-Camps Na, Sp-Isomer
• 8-Bromoadenosine-3',5'-Cyclic Monophosphorothioate Sodium Salt, Spisomer
• 8-Bromoadenosine 3',5'-Cyclic Monophosphothioate, Sp-Isomer Sodium Salt
• Sp-8-Br-Camps
• Sp-8-Br-Camps, Na
• Sp-8-Br-Camps Sodium Salt
• Adenosine, 8-bromo-, cyclic 3',5'-[hydrogen [P(S)]-phosphorothioate]
• -cyclicMonophosphothioate,Sp-Isomersodiumsalt
• 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT
• 8-Bromoadenosine3&rsquo
• 8-bromoadenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-8-br-camps),sodiumsalt
• 8-Bromoadenosine 3',5'-cyclic monophosphothiaoate, Sp-isomer sodium salt

8-Bromoadenosine 3'',5''-cyclic monophosphothiaoate, Sp-isomer sodium salt

CAS: 127634-20-2

Ref: 7W-GN5014

8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Sp-isomer sodium salt

CAS: 127634-20-2

8-Bromoadenosine 3',5'-cyclic monophosphate is a nucleotide analog that binds to RNA polymerase and blocks the elongation of RNA. It has been shown to stimulate axonal regeneration in the rat spinal cord, by increasing the level of glutamate in the extracellular space. 8-Bromoadenosine 3',5'-cyclic monophosphate also stimulates nerve growth factor (NGF) production and activates protein kinase C (PKC). This drug also inhibits apoptosis by inhibiting the activity of Mcl-1 protein, which is involved in mitochondrial membrane permeability.

Formula: C₁₀H₁₀BrN₅O₅PS·Na

Purity: Min. 95%

Color and Shape: White to off-white solid.

Molecular weight: 446.51 g/mol

Ref: 3D-NB08953