CAS 127684-08-6

7-KETOCHOLESTEROL-25,26,26,26,27,27,27-D7

Description:

7-Ketochoesterol-25,26,26,26,27,27,27-D7 is a deuterated derivative of 7-ketocholesterol, a naturally occurring oxysterol that plays a significant role in various biological processes, including cholesterol metabolism and cellular signaling. The presence of deuterium atoms in its structure enhances its stability and alters its physical properties, making it useful in research applications, particularly in mass spectrometry and metabolic studies. This compound is characterized by its hydrophobic nature, which is typical of sterols, and it exhibits a high affinity for lipid membranes. Its role in the body includes potential implications in cholesterol-related diseases and oxidative stress. The specific isotopic labeling allows for precise tracking in biological systems, aiding in the understanding of cholesterol dynamics and metabolism. As with many sterols, it may also influence cell membrane fluidity and function. Safety and handling precautions should be observed, as with all chemical substances, to mitigate any potential risks associated with its use in laboratory settings.

Formula: C₂₇H₃₇D₇O₂

InChI: InChI=1/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21?,22+,23+,25+,26+,27-/m1/s1/i1D3,2D3,17D

Synonyms:

• 7-Ketocholesterol-D7
• (3)-3-Hydroxycholest-5-en-7-one-d7
• 3-Hydroxycholest-5-en-7-one-d7
• 7-Oxocholesterol-d7
• Cholest-5-en-3-ol-7-one-d7
• SC 4722-d7
• 3-HYDROXY-5-CHOLESTENE-7-ONE-D7;7-KETOCHOLESTEROL-D7
• 3-hydroxy-5-cholestene-7-one-d7
• 7-KETOCHOLESTEROL-25,26,26,26,27,27,27-D7

7-Ketocholesterol-25,26,26,26,27,27,27-d7

CAS: 127684-08-6

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 407.69

Ref: 3U-D6045

7-Keto Cholesterol-d7

Controlled Product

CAS: 127684-08-6

Applications A labelled metabolite of Cholesterol.
References Wang, J., et al.: Biochemistry, 43, 1010 (2004), Lemaire-Ewing, S., et al.: Cell Biol. Toxicol., 21, 97 (2005), Fuda, H., et al.: J. Lipid Res., 48, 1343 ( 2007), Sasaki, H., et al.: Metabolism, 56, 357 (2007),

Formula: C₂₇₂H₇H₃₇O₂

Color and Shape: Neat

Molecular weight: 407.68

Ref: TR-K185052

7-ketocholesterol-d7

Controlled Product

CAS: 127684-08-6

7-ketocholesterol-d7 is a radiolabeled form of 7-ketocholesterol, which is an oxidation product of cholesterol. It is used in clinical practice to measure the activity and progression of cerebrotendinous xanthomatosis (CTX), a rare inherited disorder that causes inflammation in the brain and connective tissue. The radionuclide has been shown to inhibit tumor cell function and oxysterols have been shown to have bone cancer prevention effects. 7-ketocholesterol-d7 can be used as a biomarker for CTX because it accumulates in high concentrations in cerebrospinal fluid, plasma samples, and faeces. Microenvironmental factors such as cholesterol levels also affect its concentration.

Formula: C₂₇H₃₇O₂D₇

Purity: Min. 95%

Molecular weight: 407.68 g/mol

Ref: 3D-CFA68408

7-Keto Cholesterol-d7

CAS: 127684-08-6

Formula: C₂₇H₃₇D₇O₂

Color and Shape: Solid

Molecular weight: 407.6802

Ref: IN-DA009B32