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CAS 12772-57-5

:

radicicol

Description:
Radicicol, with the CAS number 12772-57-5, is a natural product belonging to the class of compounds known as ansamycins. It is primarily recognized for its role as a potent inhibitor of heat shock protein 90 (Hsp90), which is crucial for the proper folding and functioning of various client proteins, including many involved in cancer progression. Radicicol exhibits a complex structure characterized by a bicyclic core and a unique side chain, contributing to its biological activity. This compound has garnered interest in medicinal chemistry and cancer research due to its potential therapeutic applications, particularly in targeting tumor cells. Additionally, radicicol has demonstrated antifungal properties, making it relevant in the study of fungal infections. Its mechanism of action involves disrupting the chaperone function of Hsp90, leading to the degradation of client proteins. However, further research is necessary to fully understand its pharmacological profile and potential side effects in clinical settings.
Formula:C18H17ClO6
InChI:InChI=1/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3+/t9-,14-,15+/m1/s1
InChI key:InChIKey=WYZWZEOGROVVHK-GTMNPGAYSA-N
SMILES:OC1=C2C(=C(Cl)C(O)=C1)CC(=O)/C=C/C=C\[C@@]3([C@@](C[C@@H](C)OC2=O)(O3)[H])[H]
Synonyms:
  • (+)-Monorden A
  • (1aR,2E,4E,14R,15aS)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
  • (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
  • (2E,4E)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
  • 6H-Oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione, 8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-, (1aR,2Z,4E,14R,15aR)-
  • Monorden
  • Monordene
  • NSC 294404
  • Radicicol R 2146
  • Radicicol, Diheterospora chlamydosporia
  • See more synonyms
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Found 7 products.