CAS 12772-57-5: radicicol

Description: Radicicol, with the CAS number 12772-57-5, is a natural product belonging to the class of compounds known as ansamycins. It is primarily recognized for its role as a potent inhibitor of heat shock protein 90 (Hsp90), which is crucial for the proper folding and functioning of various client proteins, including many involved in cancer progression. Radicicol exhibits a complex structure characterized by a bicyclic core and a unique side chain, contributing to its biological activity. This compound has garnered interest in medicinal chemistry and cancer research due to its potential therapeutic applications, particularly in targeting tumor cells. Additionally, radicicol has demonstrated antifungal properties, making it relevant in the study of fungal infections. Its mechanism of action involves disrupting the chaperone function of Hsp90, leading to the degradation of client proteins. However, further research is necessary to fully understand its pharmacological profile and potential side effects in clinical settings.

Formula: C₁₈H₁₇ClO₆

InChI: InChI=1/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3+/t9-,14-,15+/m1/s1

InChI key: InChIKey=WYZWZEOGROVVHK-GTMNPGAYSA-N

SMILES: O=C1OC(C)CC2OC2C=CC=CC(=O)CC=3C(Cl)=C(O)C=C(O)C13

Synonyms:

• (+)-Monorden A
• (1aR,2E,4E,14R,15aS)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
• (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
• (2E,4E)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
• 6H-Oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione, 8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-, (1aR,2Z,4E,14R,15aR)-
• Monorden
• Monordene
• NSC 294404
• Radicicol R 2146
• Radicicol, Diheterospora chlamydosporia
• Radicolol
• Radisicol
• β-Resorcylic acid, 5-chloro-6-(7,8-epoxy-10-hydroxy-2-oxo-3,5-undecadienyl)-, μ-lactone
• Radicicol

Radicicol; Radisicol; Monordene; Monorden; RHI-12648; FO-4910. Es igual a MM0001

CAS: 12772-57-5

• Formula: C₁₈H₁₇ClO₆
• Purity: 99.4%
• Color and Shape: yellowish. Solid
• Molecular weight: 364.0

6H-Oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione, 8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-, (1aR,2Z,4E,14R,15aR)-

CAS: 12772-57-5

• Formula: C₁₈H₁₇ClO₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 364.777

Radicicol

CAS: 12772-57-5

Antifungal Radicicol blocks P. falciparum replication, inhibits Hsp90 (IC50: 1μM), leading to proteasomal degradation.

• Formula: C₁₈H₁₇ClO₆
• Purity: 98%
• Color and Shape: White/Yellow Powder
• Molecular weight: 364.78

Radicicol

CAS: 12772-57-5

• Formula: C₁₈H₁₇ClO₆
• Purity: By hplc: 98.77% (Typical Value in Batch COA)
• Color and Shape: yellowish amorphous solid
• Molecular weight: 364.78g/mol

Radicicol

CAS: 12772-57-5

• Formula: C₁₈H₁₇ClO₆
• Purity: ≥ 98.0%
• Color and Shape: White to yellow powder
• Molecular weight: 364.78

Radicicol

CAS: 12772-57-5

Inhibits heat shock protein 90 (HSP90); anti-cancer agent

• Formula: C₁₈H₁₇ClO₆
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 364.78 g/mol