CymitQuimica logo
HSP

HSP

HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.

Found 201 products for "HSP".

products per page.
  • GRP78-IN-3
    Targetmol
    + Info

    GRP78-IN-3

    CAS:
    GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.
    Formula:C17H18N4O2S
    Purity:99.49%
    Color and Shape:Solid
    Molecular weight:342.415

    Ref: TM-T67897

  • Ethoxyquin
    Targetmol
    + Info

    Ethoxyquin

    Controlled Product
    CAS:
    Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
    Formula:C14H19NO
    Purity:97.15% - 98.73%
    Color and Shape:Yellow Liquid
    Molecular weight:217.3068

    Ref: TM-T0756

  • IPI-493
    Targetmol
    + Info

    IPI-493

    CAS:
    IPI-493 is a bioactive chemical.
    Formula:C28H39N3O8
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:545.62

    Ref: TM-T32188

  • Novobiocin Sodium
    Targetmol
    + Info

    Novobiocin Sodium

    CAS:
    Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.
    Formula:C31H35N2NaO11
    Purity:98.46% - 99.51%
    Color and Shape:Solid
    Molecular weight:634.61

    Ref: TM-T0974

  • CC-99677
    Targetmol
    + Info

    CC-99677

    CAS:
    CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.
    Formula:C22H20ClN5O3S
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:469.944

    Ref: TM-T39321

  • Arimoclomol maleate
    Targetmol
    + Info

    Arimoclomol maleate

    CAS:
    Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.
    Formula:C18H24ClN3O7
    Purity:99.44% - 99.98%
    Color and Shape:Solid
    Molecular weight:429.852

    Ref: TM-T13554

  • Col003
    Targetmol
    + Info

    Col003

    CAS:
    Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).
    Formula:C14H11NO4
    Purity:99.03% - 99.96%
    Color and Shape:Solid
    Molecular weight:257.2414

    Ref: TM-T10860

  • Palmitic acid-13C2
    Targetmol
    + Info

    Palmitic acid-13C2

    CAS:
    13C-labeled Palmitic acid is a saturated fatty acid in animals/plants influencing GRP78 and CHOP in mouse cells.
    Formula:C16H32O2
    Molecular weight:258.415

    Ref: TM-T40980

  • Palmitic acid-D4
    Targetmol
    + Info

    Palmitic acid-D4

    CAS:
    Palmitic acid-D4 is the deuterated form of Palmitic acid. This compound is a long-chain saturated fatty acid commonly found in animals and plants. Palmitic acid (T2908) is known to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in murine granulosa cells.
    Formula:C16H32O2
    Molecular weight:260.45

    Ref: TM-TMID-0977

  • trans-Dehydrocurvularin
    Targetmol
    + Info

    trans-Dehydrocurvularin

    CAS:
    trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.
    Formula:C16H18O5
    Color and Shape:Solid
    Molecular weight:290.315

    Ref: TM-T125357

  • CymitQuimica logo
    Targetmol
    + Info

    Grp94-IN-3

    Grp94-IN-3 (Compound 47) is a selective Grp94 ATP-competitive inhibitor with a dissociation constant (Kd) of 76 nM. It exhibits significantly lower affinity for Hsp90α, with a Kd of 9.17 μM. Grp94-IN-3 induces degradation of Integrin α2 (Integrinα2) in MDA-MB-231 cells and reduces intracellular accumulation of mutant myocilin in human trabecular meshwork cells. This compound is useful in research on metastatic cancers and open-angle glaucoma.

    Ref: TM-T214222

  • Grp94 Inhibitor-2
    Targetmol
    + Info

    Grp94 Inhibitor-2

    Grp94 Inhibitor-2 (compound 23) is a cyclopropane analog that exhibits high affinity for Glucose Regulated Protein 94 (Grp94), with dissociation constants (Kd) of 0.48 µM for Grp94 and 0.65 µM for Hsp90α.
    Formula:C26H25ClFNO4
    Molecular weight:469.94

    Ref: TM-T89400

  • NMS-E973
    Targetmol
    + Info

    NMS-E973

    CAS:
    NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
    Formula:C22H22N4O7
    Purity:99.84%
    Color and Shape:Yellow Solid
    Molecular weight:454.4327

    Ref: TM-T6609

  • CymitQuimica logo
    Targetmol
    + Info

    TBPH

    TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.

    Ref: TM-T211712

  • Palmitic acid-13C sodium
    Targetmol
    + Info

    Palmitic acid-13C sodium

    CAS:
    13C-labeled Palmitic acid, a common long-chain fatty acid in flora/fauna, induces GRP78/CHOP in mouse cells.
    Formula:CC15H31NaO2
    Molecular weight:279.4

    Ref: TM-T39423

  • HEMTAC WEE1 degrader-1
    Targetmol
    + Info

    HEMTAC WEE1 degrader-1

    CAS:
    HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.
    Formula:C57H71N15O6
    Color and Shape:Solid
    Molecular weight:1062.27

    Ref: TM-T207012

  • Shepherdin (79-87)
    Targetmol
    + Info

    Shepherdin (79-87)

    CAS:
    Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.
    Formula:C41H64N12O12S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:949.09

    Ref: TM-T12896

  • [Au(TPP)]Cl
    Targetmol
    + Info

    [Au(TPP)]Cl

    CAS:
    [Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and exhibits anticancer properties.'
    Formula:C44H28AuClN4
    Molecular weight:845.14

    Ref: TM-T88478

  • CymitQuimica logo
    Targetmol
    + Info

    Hsp90β-IN-2

    Hsp90β-IN-2 (Compound 16B) is a selective inhibitor of Hsp90β, with dissociation constants (KD) of 225 nM for Hsp90β and 73.32 μM for Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231, A549, and SKOV-3 cells, and is applicable in research on triple-negative breast cancer.

    Ref: TM-T213425

  • JD-13
    Targetmol
    + Info

    JD-13

    CAS:
    JD-13 is a selective GPR119 agonist; promotes insulin and GLP-1 release; glucose homeostasis; diabetes research tool.
    Formula:C25H32N4O3
    Purity:99.32% - 99.69%
    Color and Shape:White Solid
    Molecular weight:436.56

    Ref: TM-T212638