HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 197 products for "HSP".
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GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Formula:C17H18N4O2SPurity:99.49%Color and Shape:SolidMolecular weight:342.415IPI-493
CAS:IPI-493 is a bioactive chemical.Formula:C28H39N3O8Purity:99.86%Color and Shape:SolidMolecular weight:545.62CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Formula:C22H20ClN5O3SPurity:99.59%Color and Shape:SolidMolecular weight:469.944Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Formula:C14H11NO4Purity:99.03% - 99.96%Color and Shape:SolidMolecular weight:257.2414Novobiocin Sodium
CAS:Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Formula:C31H35N2NaO11Purity:99% - 99.51%Color and Shape:SolidMolecular weight:634.6062Ethoxyquin
CAS:Controlled ProductEthoxyquin (Santoflex) is an antioxidant used in animal feeds.Formula:C14H19NOPurity:97.15% - 98.73%Color and Shape:Yellow LiquidMolecular weight:217.3068Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formula:C18H24ClN3O7Purity:99.44% - 99.98%Color and Shape:SolidMolecular weight:429.852Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Formula:C34H49F3N4O10Color and Shape:SolidMolecular weight:730.34008Hsp90β-IN-2
Hsp90β-IN-2 (Compound 16B) is a selective inhibitor of Hsp90β, with dissociation constants (KD) of 225 nM for Hsp90β and 73.32 μM for Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231, A549, and SKOV-3 cells, and is applicable in research on triple-negative breast cancer.Cemdomespib
CAS:Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Formula:C24H30FNO6Color and Shape:SolidMolecular weight:447.5TBPH
TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.3-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Formula:C13H11N5O2Purity:99.88%Color and Shape:SolidMolecular weight:269.2587NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Formula:C22H22N4O7Purity:99.84%Color and Shape:Yellow SolidMolecular weight:454.4327[Au(TPP)]Cl
CAS:[Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and exhibits anticancer properties.'Formula:C44H28AuClN4Molecular weight:845.14JG-258
CAS:JG-258 is an inactive negative control for Hsp70 inhibitors [1] .Formula:C20H22ClN3OS3Color and Shape:SolidMolecular weight:452.06trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Formula:C16H18O5Color and Shape:SolidMolecular weight:290.315Grp94 Inhibitor-2
Grp94 Inhibitor-2 (compound 23) is a cyclopropane analog that exhibits high affinity for Glucose Regulated Protein 94 (Grp94), with dissociation constants (Kd) of 0.48 µM for Grp94 and 0.65 µM for Hsp90α.Formula:C26H25ClFNO4Molecular weight:469.946BrCaQ-C10-TPP
6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.Formula:C45H47Br2N2O3PColor and Shape:SolidMolecular weight:854.65HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formula:C57H71N15O6Color and Shape:SolidMolecular weight:1062.27Grp94-IN-3
Grp94-IN-3 (Compound 47) is a selective Grp94 ATP-competitive inhibitor with a dissociation constant (Kd) of 76 nM. It exhibits significantly lower affinity for Hsp90α, with a Kd of 9.17 μM. Grp94-IN-3 induces degradation of Integrin α2 (Integrinα2) in MDA-MB-231 cells and reduces intracellular accumulation of mutant myocilin in human trabecular meshwork cells. This compound is useful in research on metastatic cancers and open-angle glaucoma.
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