CAS 127779-20-8

Saquinavir

Description:

Saquinavir is an antiretroviral medication primarily used in the treatment of HIV/AIDS. It belongs to the class of protease inhibitors, which work by inhibiting the protease enzyme, crucial for the viral replication process. Saquinavir is characterized by its relatively low bioavailability when taken orally, necessitating its administration in combination with other antiretroviral agents to enhance its efficacy. The compound is typically presented as a mesylate salt, which improves its solubility and stability. Chemically, Saquinavir features a complex structure that includes multiple chiral centers, contributing to its pharmacological activity. It is known for its side effects, which can include gastrointestinal disturbances and potential interactions with other medications due to its metabolism via the cytochrome P450 system. Saquinavir's development marked a significant advancement in HIV treatment, and it is often used in combination therapy to achieve better viral suppression and improve patient outcomes.

Formula: C₃₈H₅₀N₆O₅

InChI: InChI=1/C38H50N6O5/c1-38(2,3)43-37(49)32-20-26-14-7-8-15-27(26)22-44(32)23-33(45)30(19-24-11-5-4-6-12-24)41-36(48)31(21-34(39)46)42-35(47)29-18-17-25-13-9-10-16-28(25)40-29/h4-6,9-13,16-18,26-27,30-33,45H,7-8,14-15,19-23H2,1-3H3,(H2,39,46)(H,41,48)(H,42,47)(H,43,49)/t26-,27+,30-,31-,32-,33+/m0/s1

InChI key: InChIKey=QWAXKHKRTORLEM-UGJKXSETSA-N

SMILES: C([C@H]([C@H](CC1=CC=CC=C1)NC([C@@H](NC(=O)C2=NC3=C(C=C2)C=CC=C3)CC(N)=O)=O)O)N4[C@H](C(NC(C)(C)C)=O)C[C@]5([C@@](C4)(CCCC5)[H])[H]

Synonyms:

• Ro 31-8959
• Butanediamide, N1-[3-[3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, [3S-[2[1R*(R*),2S*],3α,4aβ,8aβ]]-
• (S)-N-[(αS)-α-[(1R)-2-[(3S,4aS,8aS)-3-(tert-Butylcarbamoyl)octahydro-2(1H)-isoquinolyl]-1-hydroxyethyl]phenethyl]-2-quinaldamidosuccinamide
• (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-Dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide
• Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-
• N~1~-{(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}-N~2~-(quinolin-2-ylcarbonyl)-L-aspartamide
• N~1~-{(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}-N~2~-(quinolin-2-ylcarbonyl)-L-aspartamide
• SAQUINAVIRMESYLATE(SUBJECTTOPATENTFREE)
• Ro 31-8959/000
• (3S)-N-tert-Butyl-2-[(2R,3S)-3-[N-(2-quinolinylcarbonyl)-3-carbamoylalanylamino]-2-hydroxy-4-phenylbutyl]-1,2,3,4,4aβ,5,6,7,8,8aβ-decahydroisoquinoline-3α-carboxamide
• (4aS,8aβ)-N-tert-Butyldecahydro-2-[(2R,3S)-2-hydroxy-4-phenyl-3-[[(2S)-3-carbamoyl-2-(2-quinolinylcarbonylamino)propanoyl]amino]butyl]isoquinoline-3α-carboxamide
• Ro-31-8959/003：Invirase
• SAGUINAVIR
• FLUNIXIN
• FLUNIXINE
• SAQUINAVIR
• n1-[(1s,2r)-3-[(3s,4as,8as)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1h)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-butanediamide
• (2S)-N-[(2S,3R)-4-[(3S,4AS,8AS)-3-(TERT-BUTYLCARBAMOYL)-3,4,4A,5,6,7,8,8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2-(QUINOLINE-2-CARBONYLAMINO)BUTANEDIAMIDE
• 2-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]AMINO]PYRIDINE-3-CARBOXYLIC ACID
• Sch 52852
• Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-(9CI)

(2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide

CAS: 127779-20-8

Formula: C₃₈H₅₀N₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 670.8408

Ref: IN-DA019FSP

Saquinavir-d9

CAS: 127779-20-8

Formula: C₃₈H₄₁D₉N₆O₅

Purity: ≥ 95%

Color and Shape: White to off-white solid

Molecular weight: 679.90

Ref: 7W-GX7696

Saquinavir

CAS: 127779-20-8

Saquinavir

Purity: ≥98%

Molecular weight: 670.84g/mol

Ref: 54-BUP14427

Saquinavir

CAS: 127779-20-8

Saquinavir (Ro 31-8959) is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.

Formula: C₃₈H₅₀N₆O₅

Purity: 99.50% - >99.99%

Color and Shape: Solid

Molecular weight: 670.84

Ref: TM-T7903

Saquinavir

Controlled Product

CAS: 127779-20-8

Applications Saquinavir (CAS# 127779-20-8) is a useful research chemical compound.

Formula: C₃₈H₅₀N₆O₅

Color and Shape: White To Off-White

Molecular weight: 670.84

Ref: TR-S212810

Saquinavir

CAS: 127779-20-8

Anti-viral; HIV protease inhibitor

Formula: C₃₈H₅₀N₆O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 670.84 g/mol

Ref: 3D-FS61498

Saquinavir - Bio-X ™

CAS: 127779-20-8

Saquinavir is a HIV protease inhibitor drug that is used with other antiretroviral drugs for the treatment of HIV-1. As this drug prevents HIV protease activity, it prevents the proteolysis of the Gag polyprotein and thus results in non-infectious virus particles.

Formula: C₃₈H₅₀N₆O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 670.84 g/mol

Ref: 3D-BS164390

Saquinavir

CAS: 127779-20-8

Formula: C₃₈H₅₀N₆O₅

Purity: 98%

Molecular weight: 670.855

Ref: 10-F547238