CAS 127785-64-2

Basifungin

Description:

Basifungin, with the CAS number 127785-64-2, is a cyclic lipopeptide antibiotic primarily known for its antifungal properties. It is produced by certain strains of the fungus *Bacillus subtilis*. Basifungin exhibits a unique mechanism of action by inhibiting the synthesis of glucan in the fungal cell wall, which is crucial for maintaining cell integrity and structure. This makes it effective against a variety of fungal pathogens. The compound is characterized by its complex structure, which includes a cyclic peptide backbone and a fatty acid side chain, contributing to its bioactivity and solubility. Basifungin has shown potential in treating various fungal infections, particularly in immunocompromised patients. Its efficacy and safety profile are subjects of ongoing research, as it may offer an alternative to existing antifungal therapies, especially in cases of resistance. Overall, Basifungin represents a significant advancement in the field of antifungal agents, with its unique properties and mechanisms of action.

Formula: C₆₀H₉₂N₈O₁₁

InChI: InChI=1/C60H92N8O11/c1-17-38(9)46-57(75)65(14)47(36(5)6)52(70)61-42(32-35(3)4)55(73)67(16)50(60(11,12)78)59(77)79-49(39(10)18-2)58(76)66(15)48(37(7)8)53(71)62-43(33-40-26-21-19-22-27-40)54(72)64(13)45(34-41-28-23-20-24-29-41)56(74)68-31-25-30-44(68)51(69)63-46/h19-24,26-29,35-39,42-50,78H,17-18,25,30-34H2,1-16H3,(H,61,70)(H,62,71)(H,63,69)/t38-,39-,42+,43+,44+,45+,46-,47+,48+,49+,50-/m1/s1

Synonyms:

• Ly 295337
• Aureobasidin A
• Basifungin [USAN:INN]
• Valine, 3-hydroxy-N-(N-(N-(N-(1-(N-(N-(N-(2-hydroxy-3-methyl-1-oxopentyl)-N-methylvalyl)phenylalanyl)-N-methylphenylalanyl)prolyl)alloisoleucyl)-N-methylvalyl)leucyl)-N-methyl-, alpha-1-lactone
• (3R,6S,9S,12S,15S,18S,21S,24S,29aS)-21,24-dibenzyl-3,15-di[(2R)-butan-2-yl]-12-(2-hydroxypropan-2-yl)-5,11,17,23-tetramethyl-9-(2-methylpropyl)-6,18-di(propan-2-yl)octadecahydro-1H,15H-pyrrolo[1,2-m][1,4,7,10,13,16,19,22,25]oxaoctaazacycloheptacosine-1,4,7,10,13,16,19,22,25-nonone
• UNII-VV0USO6I6U
• Antibiotic R106I
• N-((2R,3R)-2-Hydroxy-3-methylvaleryl)-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl-L-alloisoleucyl-N-methyl-L-valyl-L-leucyl-3-hydroxy-N-methyl-L-valine alpha1-lactone

Basifungin

CAS: 127785-64-2

Formula: C₆₀H₉₂N₈O₁₁

Purity: 99%

Color and Shape: Solid

Molecular weight: 1101.4195

Ref: IN-DA009VRK

Aureobasidin A

CAS: 127785-64-2

Aureobasidin A

Purity: ≥98%

Molecular weight: 1101.42g/mol

Ref: 54-BUP03458

Aureobasidin A

CAS: 127785-64-2

Aureobasidin A is a cyclic peptide and an antifungal antibiotic. Aureobasidin A is an inhibitor of the inositolphosphorylceramide synthase AUR1.

Formula: C₆₀H₉₂N₈O₁₁

Purity: 98.57%

Color and Shape: Solid

Molecular weight: 1101.42

Ref: TM-T9267

Basifungin

CAS: 127785-64-2

An inhibitor of the inositolphosphorylceramide synthase AUR1.

Formula: C₆₀H₉₂N₈O₁₁

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,101.4 g/mol

Ref: 3D-CFA78564