CAS 1279026-26-4

BENAZEPRIL-D5 HYDROCHLORIDE

Description:

Benazepril-D5 hydrochloride is a deuterated form of benazepril, an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. The "D5" designation indicates that five hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen, which can be useful in pharmacokinetic studies and metabolic research. This compound retains the pharmacological properties of benazepril, functioning by inhibiting the ACE enzyme, thereby reducing the production of angiotensin II, a potent vasoconstrictor. The hydrochloride salt form enhances its solubility and stability. Benazepril-D5 hydrochloride is typically characterized by its molecular structure, which includes a carboxylate group and a phenyl ring, contributing to its biological activity. As a research chemical, it is often utilized in studies to trace metabolic pathways and understand drug interactions without interference from the natural hydrogen isotopes present in the body. Safety and handling precautions should be observed, as with any pharmaceutical compound.

Formula: C₂₄H₂₉ClN₂O₅

Synonyms:

• Benazepril hydrochloride salt
• [2H5]-Benazepril Hydrochloride
• BENAZEPRIL-D5 HYDROCHLORIDE
• Benazepril hydrochloride D5

Benazepril-d5 HCl

CAS: 1279026-26-4

Formula: C₂₄H₂₃D₅N₂O₅·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 429.53 36.46

Ref: 4Z-B-013

Benazepril-d5 Hydrochloride

Controlled Product

CAS: 1279026-26-4

Applications Benazepril-d5 Hydrochloride is the labeled analogue of Benazepril Hydrochloride (B119750), which is used as an antihypertensive; angiotensin converting enzyme inhibitor.
References Schaller, M.D., et al.: Eur. J. Clin. Pharmacol., 28, 267 (985); Colfer, H.T., et al.: Am. J. Cardiol., 70, 354 (1992)

Formula: C₂₄H₂₄D₅ClN₂O₅

Color and Shape: Neat

Molecular weight: 465.98

Ref: TR-B119753

Benazepril-d5 hydrochloride

CAS: 1279026-26-4

Benazepril is a pharmaceutical drug that belongs to the group of model drugs. It is a prodrug, which undergoes bioactivation in vivo to benazeprilat, its active form. Benazepril is used as a treatment for high blood pressure and congestive heart failure. The concentration of benazepril in plasma can be measured using an ionization mass spectrometer (IMS) with an inorganic method or a liquid chromatography-mass spectrometer (LC-MS). The IMS technique uses deuterated benazepril as the internal standard and calibrates the instrumentation parameters with this compound. A calibration curve is then constructed from the standards and applied to samples that are analyzed by LC-MS. This calibration curve can be used for quantitation of benazepril at low levels.

Formula: C₂₄H₂₃D₅N₂O₅•HCl

Purity: Min. 95%

Molecular weight: 465.98 g/mol

Ref: 3D-EBC02626