CAS 1279200-03-1

BENAZEPRIL-D5

Description:

Benazepril-D5 is a deuterated form of benazepril, an angiotensin-converting enzyme (ACE) inhibitor commonly used in the treatment of hypertension and heart failure. The deuterated version, indicated by the "D5" in its name, contains five deuterium atoms, which are isotopes of hydrogen. This modification can enhance the stability and metabolic tracking of the compound in pharmacokinetic studies. Benazepril itself works by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. The presence of deuterium in Benazepril-D5 may also influence its pharmacological properties, such as its half-life and bioavailability, making it useful in research settings to study drug metabolism and efficacy. As with other ACE inhibitors, potential side effects may include cough, elevated potassium levels, and renal impairment. Overall, Benazepril-D5 serves as a valuable tool in both clinical and research applications, particularly in understanding the dynamics of ACE inhibition and its therapeutic effects.

Formula: C₂₄H₂₃D₅N₂O₅

InChI: InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1/i3D,4D,5D,8D,9D

InChI key: InChIKey=XPCFTKFZXHTYIP-DPINEGQSSA-N

SMILES: C(C(O)=O)N1C=2C(CC[C@H](N[C@@H](CCC3=C(C(=C(C(=C3[2H])[2H])[2H])[2H])[2H])C(OCC)=O)C1=O)=CC=CC2

Synonyms:

• BENAZEPRIL-D5
• 2-[(3S)-3-[[(2S)-1-Ethoxy-1-oxo-4-(2,3,4,5,6-pentadeuteriophenyl)butan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid

Benazepril-d5

CAS: 1279200-03-1

Benazepril is a drug that belongs to the losartan group of drugs. It works by inhibiting the enzyme in the angiotensin system, which is responsible for regulating blood pressure. Benazepril-d5 has been shown to be effective in treating hypertension and congestive heart failure. This drug also helps to treat diabetic neuropathy, systolic hypertension, and cardiac hypertrophy. Benazepril-d5 can also be used as a long-term treatment for congestive heart failure and diastolic hypertension.

Formula: C₂₄H₂₈N₂O₅

Purity: Min. 95%

Molecular weight: 429.5 g/mol

Ref: 3D-EBC20003