CAS 127951-99-9

Hydrodolasetron

Description:

Hydrodolasetron, identified by its CAS number 127951-99-9, is a chemical compound that belongs to the class of 5-HT3 receptor antagonists. It is primarily utilized in the medical field for its antiemetic properties, particularly in the prevention and treatment of nausea and vomiting associated with chemotherapy and surgery. The compound works by blocking serotonin receptors in the gastrointestinal tract and the central nervous system, thereby inhibiting the vomiting reflex. Hydrodolasetron is characterized by its relatively high potency and selectivity for the 5-HT3 receptor, which contributes to its effectiveness. In terms of physical properties, it is typically presented as a white to off-white crystalline powder, and it is soluble in water and various organic solvents. As with many pharmaceuticals, it is essential to consider its pharmacokinetics, including absorption, distribution, metabolism, and excretion, which influence its therapeutic efficacy and safety profile. Overall, Hydrodolasetron represents an important option in the management of chemotherapy-induced nausea and vomiting.

Formula: C₁₉H₂₂N₂O₃

InChI: InChI=1/C19H22N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,18,20,22H,5-8,10H2

InChI key: InChIKey=MLWGAEVSWJXOQJ-UHFFFAOYSA-N

SMILES: O(C(=O)C=1C=2C(NC1)=CC=CC2)C3CC4N5C(CC(C4)C(O)C5)C3

Synonyms:

• 10-Hydroxy-8-azatricyclo[5.3.1.0~3,8~]undec-5-yl 1H-indole-3-carboxylate
• 1H-Indole-3-carboxylic acid, octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl ester
• 2,6-Methano-2H-quinolizine, 1H-indole-3-carboxylic acid deriv.
• Hydrodolasetron
• Mdl 74156
• Reduced dolasetron
• MLWGAEVSWJXOQJ-UHFFFAOYSA-N
• Dolasetron Hydroxy Impurity
• Dolasetron Impurity 1 (Hydrodolasetron)

Hydrodolasetron

CAS: 127951-99-9

Formula: C₁₉H₂₂N₂O₃

Color and Shape: Solid

Molecular weight: 326.3896

Ref: IN-DA000XL6

Hydrodolasetron-d4 (Indole-d4)

CAS: 127951-99-9

Formula: C₁₉H₁₈D₄N₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 330.42

Ref: 4Z-D-097004

Hydrodolasetron

CAS: 127951-99-9

Formula: C₁₉H₂₂N₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 326.40

Ref: 4Z-D-097003

Hydrodolasetron

Controlled Product

CAS: 127951-99-9

Applications Hydrodolasetron, is the reduced form of Dolasetron (D528500), a specific serotonin (5HT3) receptor antagonist. Antiemetic.
References Boeijinga, P.H., et al.: Eur. J. Pharmacol., 219, 9 (1992), Miller, R.C., et al., Drug Dev. Res., 28, 87 (1993), Fauser, A.A., et al.: Eur. J. Cancer, 32, 1523 (1996), Graczyk, S.G., et al.: Anesth. Analg., 84, 325 (1997),

Formula: C₁₉H₂₂N₂O₃

Color and Shape: White To Off-White

Molecular weight: 326.39

Ref: TR-H714755

Hydrodolasetron

CAS: 127951-99-9

Formula: C₁₉H₂₂N₂O₃

Molecular weight: 326.40

Ref: ST-EA-CP-D39006

MDL-74156

CAS: 127951-99-9

MDL-74156 is an active metabolite of dolasetron and a 5-hydroxy-tryptamine3 (5-HT3) antagonist.

Formula: C₁₉H₂₂N₂O₃

Color and Shape: Solid

Molecular weight: 326.39

Ref: TM-T71064