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CAS 127956-27-8

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6-(difluoromethyl)indole

Description:
6-(Difluoromethyl)indole is a chemical compound characterized by its indole structure, which consists of a fused benzene and pyrrole ring. The presence of a difluoromethyl group at the 6-position of the indole ring significantly influences its chemical properties and reactivity. This compound is typically a solid at room temperature and exhibits moderate solubility in organic solvents. The difluoromethyl group introduces unique electronic and steric effects, making it of interest in medicinal chemistry and material science. It may exhibit biological activity, potentially serving as a scaffold for drug development, particularly in targeting specific biological pathways. Additionally, the presence of fluorine atoms can enhance metabolic stability and lipophilicity, which are desirable traits in pharmaceutical compounds. As with many indole derivatives, 6-(difluoromethyl)indole may also participate in various chemical reactions, including electrophilic substitutions and coupling reactions, making it a versatile intermediate in organic synthesis. Safety and handling precautions should be observed, as with all chemical substances, due to potential toxicity and reactivity.
Formula:C9H7F2N
InChI:InChI=1/C9H7F2N/c10-9(11)7-2-1-6-3-4-12-8(6)5-7/h1-5,9,12H
SMILES:c1cc(cc2c1cc[nH]2)C(F)F
Synonyms:
  • 6-(difluoromethyl)-1H-indole
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