CAS 128-20-1

Pregnanolone

Description:

Pregnanolone is a naturally occurring steroid and a neuroactive metabolite of progesterone, classified as a neurosteroid. It is characterized by its role in modulating the activity of neurotransmitter receptors, particularly GABA(A) receptors, which can influence mood, anxiety, and cognitive functions. Pregnanolone is a white crystalline solid at room temperature and is soluble in organic solvents such as ethanol and chloroform, but has limited solubility in water. Its molecular formula is C21H34O2, and it features a steroid backbone with a hydroxyl group, contributing to its biological activity. Pregnanolone is involved in various physiological processes, including the regulation of the menstrual cycle and the development of the central nervous system. Additionally, it has been studied for its potential therapeutic effects in conditions such as anxiety disorders and neurodegenerative diseases. Due to its neuroactive properties, it is of interest in pharmacological research, although its clinical applications are still being explored.

Formula: C₂₁H₃₄O₂

InChI: InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1

InChI key: InChIKey=AURFZBICLPNKBZ-YZRLXODZSA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CC[C@@]1(C[C@H](O)CC2)[H])[H])[H]

Synonyms:

• (3Alpha)-3-Hydroxypregnan-20-One
• (3Alpha,5Beta)-3-Hydroxypregnan-20-One
• (3α,5β)-3-Hydroxypregnan-20-one
• 3-Alpha-Hydroxy-5-Beta-Pregnan-20-One
• 3-Deoxo-3α-hydroxy-5β-dihydroprogesterone
• 3-Hydroxypregnan-20-One
• 3alpha,5beta-Epimeric pregnanolone
• 3alpha-Hydroxy-5beta-pregnan-20-one
• 3alpha-Hydroxy-5beta-tetrahydroprogesterone
• 3α,5β-Pregnanolone
• 3α,5β-Tetrahydroprogesterone
• 3α-Hydroxy-20-oxo-5β-pregnane
• 3α-Hydroxy-5β,17β-pregnan-20-one
• 3α-Hydroxy-5β-pregnan-20-one
• 3α-Hydroxy-5β-tetrahydroprogesterone
• 5β-Pregnan-20-one, 3α-hydroxy-
• 5β-Pregnane-3α-ol-20-one
• Eltanolone
• Kabi 2213
• NSC 82867
• Pregnan-20-one, 3-hydroxy-, (3α,5β)-
• Pregnan-3alpha-ol-20-one
• Pregnan-3α-ol-20-one
• Pregnanolone
• Pregnanolone II
• Skf 6455

3α-Hydroxy-5β-tetrahydroprogesterone

CAS: 128-20-1

Formula: C₂₁H₃₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 318.4935

Ref: IN-DA000XO1

Pregnanolone

CAS: 128-20-1

Formula: C₂₁H₃₄O₂

Molecular weight: 318.50

Ref: 4Z-P-3294

5β-Pregnan-3α-ol-20-one

CAS: 128-20-1

Formula: C₂₁H₃₄O₂

Molecular weight: 318.49

Ref: 7W-GK1545

5β-Pregnan-3α-ol-20-one

CAS: 128-20-1

Formula: C₂₁H₃₄O₂

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 318.50

Ref: 3B-P3084

Pregnanolone-d4

CAS: 128-20-1

Formula: C₂₁H₃₀D₄O₂

Molecular weight: 322.53

Ref: 4Z-P-3295

5beta-Pregnan-3alpha-ol-20-one

Controlled Product

CAS: 128-20-1

Applications A hyponotic-anaesthetic agent.
References Gyermek, et al.: J. Med. Chem., 11, 117 (1968)

Formula: C₂₁H₃₄O₂

Color and Shape: Neat

Molecular weight: 318.5

Ref: TR-P711300

5β-Pregnan-3α-ol-20-one

Controlled Product

CAS: 128-20-1

5b-Pregnan-3a-ol-20-one is a natural product that belongs to the group of steroids. It has been shown to inhibit the polymerase chain reaction in animals. The drug also inhibits pain and has been shown to be effective in models of epilepsy. 5b-Pregnan-3a-ol-20-one binds to DNA, preventing transcription and replication. It also stabilizes the surface of cells, which may be important for its uptake by cells. This compound interacts with Tlr4, which may activate immune cells and lead to seizures. 5b-Pregnan-3a-ol-20-one is oxidized by cytochrome P450 enzymes, leading to the production of hydrogen peroxide and formation of a carbonyl group on the molecule.

Formula: C₂₁H₃₄O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 318.49 g/mol

Ref: 3D-FP27148

Pregnanolone

CAS: 128-20-1

Formula: C₂₁H₃₄O₂

Molecular weight: 318.5

Ref: ST-EA-CP-P133085