CAS 128-23-4

5β-Dihydroprogesterone

Description:

5β-Dihydroprogesterone, also known as 5β-pregnane-3,20-dione, is a steroid hormone that is a derivative of progesterone. It is characterized by its structure, which includes a steroid backbone with a ketone group at the C3 and C20 positions. This compound is typically found in the human body as a metabolite of progesterone and plays a role in various physiological processes, including the regulation of the menstrual cycle and pregnancy. It exhibits progestational activity, influencing the endometrium and maintaining pregnancy. The compound is lipophilic, allowing it to easily cross cell membranes and interact with steroid hormone receptors. Its pharmacological properties include potential effects on the central nervous system and implications in reproductive health. 5β-Dihydroprogesterone is also of interest in research related to hormone replacement therapy and contraceptive development. As with many steroids, it is important to consider its effects on metabolism and its potential side effects when used therapeutically.

Formula: C₂₁H₃₂O₂

InChI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16+,17-,18+,19+,20+,21-/m1/s1

InChI key: InChIKey=XMRPGKVKISIQBV-XWOJZHJZSA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CC[C@@]1(CC(=O)CC2)[H])[H])[H]

Synonyms:

• 5-Beta-Pregnane-3,20-Dione
• 5β-Dihydroprogesterone
• 5β-Pregnan-3,20-dione
• NSC 82868
• Pregnane-3,20-Dione
• Pregnane-3,20-dione, (5β)-
• U 2411
• 5β-Pregnane-3,20-dione
• (5β)-Pregnane-3,20-dione

Pregnane-3,20-dione, (5β)-

CAS: 128-23-4

Formula: C₂₁H₃₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 316.4776

Ref: IN-DA000XO0

5β-Dihydroprogesterone

CAS: 128-23-4

5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP

Formula: C₂₁H₃₂O₂

Color and Shape: Solid

Molecular weight: 316.485

Ref: TM-T37319

5β-Dihydro Progesterone

Controlled Product

CAS: 128-23-4

Applications A metabolite of the neuroactive steroid Progesterone (PROG) (P755900).
References Wiebe, J., et al.: Cancer Res., 60, 936 (2000), Lacasa, D., et al.: J. Biol. Chem., 276, 11512 (2001), Johansson, I., et al.: Brain Res., 934, 125 (2002), Leonhardt, S., et al.: Steroids, 68, 761 (2003),

Formula: C₂₁H₃₂O₂

Color and Shape: Neat

Molecular weight: 316.48

Ref: TR-D449280

5β-Dihydro Progesterone-d8

Controlled Product

CAS: 128-23-4

Applications 5β-Dihydro Progesterone-d8 is labelled which is labelled 5β-Dihydro Progesterone (D449280), a metabolite of the neuroactive steroid Progesterone (PROG) (P755900).
References Wiebe, J., et al.: Cancer Res., 60, 936 (2000), Lacasa, D., et al.: J. Biol. Chem., 276, 11512 (2001), Johansson, I., et al.: Brain Res., 934, 125 (2002), Leonhardt, S., et al.: Steroids, 68, 761 (2003),

Formula: C₂₁H₂₄D₈O₂

Color and Shape: Neat

Molecular weight: 324.53

Ref: TR-D449282

5b-Dihydro progesterone

Controlled Product

CAS: 128-23-4

Progesterone is a hormone that has multiple functions in females during their reproductive cycle. It is an important component of the female reproductive system, and it is mainly synthesized by the corpus luteum of the ovary. Progesterone is also found in other tissues, including cardiac tissue, brain, skin, and endometrium. In addition to its role as a progestin in hormonal contraception and as a treatment for menorrhagia and endometrial cancer, progesterone has been used as an antidepressant treatment to prevent postpartum depression. Progesterone can be synthesized from cholesterol or pregnenolone through two pathways: the side-chain cleavage pathway or the C-21 pathway. The side-chain cleavage pathway involves 5b-reduction and 5b-oxidation reactions while the C-21 pathway results in 3a-hydroxylation followed by 4b-hydroxylation reactions. Progesterone binds

Formula: C₂₁H₃₂O₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 316.48 g/mol

Ref: 3D-FD21938