CAS 128095-54-5

4-trifluoromethylumbelliferyl iduronide

Description:

4-Trifluoromethylumbelliferyl iduronide is a chemical compound that serves as a substrate in biochemical assays, particularly for the detection of iduronidase activity, which is relevant in the context of certain lysosomal storage disorders. This compound features a trifluoromethyl group, which enhances its lipophilicity and may influence its interaction with biological systems. The umbelliferyl moiety is commonly used in fluorogenic substrates due to its ability to emit fluorescence upon enzymatic cleavage, making it useful for monitoring enzymatic reactions. The iduronide part of the molecule indicates that it is a derivative of iduronic acid, which is a component of glycosaminoglycans. The presence of the trifluoromethyl group can also affect the compound's stability and reactivity. Overall, 4-trifluoromethylumbelliferyl iduronide is characterized by its utility in enzymatic assays, its structural features that enhance fluorescence, and its relevance in biochemical research related to metabolic disorders.

Formula: C₁₆H₁₃F₃O₉

InChI: InChI=1/C16H13F3O9/c17-16(18,19)7-4-9(20)27-8-3-5(1-2-6(7)8)26-15-12(23)10(21)11(22)13(28-15)14(24)25/h1-4,10-13,15,21-23H,(H,24,25)/t10-,11-,12+,13+,15+/m0/s1

Synonyms:

• 4-Tfmu
• 4-Trifluoromethylumbelliferyl-alpha-L-iduronide
• 2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl alpha-L-idopyranosiduronic acid