CAS 128120-02-5

1-phenylpyrrolidin-3-one

Description:

1-Phenylpyrrolidin-3-one, also known by its chemical structure featuring a pyrrolidine ring with a phenyl group and a ketone functional group, is a compound that exhibits characteristics typical of both cyclic amines and aromatic compounds. It is a white to off-white solid at room temperature and is soluble in organic solvents such as ethanol and acetone, but has limited solubility in water. The presence of the phenyl group contributes to its aromatic properties, while the pyrrolidinone structure imparts potential biological activity. This compound is of interest in medicinal chemistry and research due to its potential applications in drug development and as a precursor in the synthesis of various pharmaceuticals. Its molecular structure allows for interactions with biological targets, making it a subject of study in the context of neuropharmacology and other fields. Safety data should be consulted for handling and usage, as with any chemical substance, to ensure proper precautions are taken.

Formula: C₁₀H₁₁NO

InChI: InChI=1/C10H11NO/c12-10-6-7-11(8-10)9-4-2-1-3-5-9/h1-5H,6-8H2

SMILES: c1ccc(cc1)N1CCC(=O)C1

1-Phenylpyrrolidin-3-one

CAS: 128120-02-5

Formula: C₁₀H₁₁NO

Molecular weight: 161.2004

Ref: IN-DA000XST

1-phenylpyrrolidin-3-one

CAS: 128120-02-5

Formula: C₁₀H₁₁NO

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 161.204

Ref: 10-F309564

1-Phenyl-3-pyrrolidinone

Controlled Product

CAS: 128120-02-5

Formula: C₁₀H₁₁NO

Color and Shape: Neat

Molecular weight: 389.354

Ref: TR-P336730

1-Phenyl-3-pyrrolidinone-d5

Controlled Product

CAS: 128120-02-5

Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.
References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014

Formula: C₁₀D₅H₆NO

Color and Shape: Neat

Molecular weight: 166.231

Ref: TR-P336732

1-Phenyl-3-pyrrolidinone

CAS: 128120-02-5

1-Phenyl-3-pyrrolidinone (1PP) is a cytotoxic agent that inhibits the growth of tumor cells. It has been shown to have activity against leukemia, lymphocytic leukemia, and human colon adenocarcinoma cells. The 1PP binds to the phenyl ring and interacts with DNA in a manner similar to adriamycin. This binding blocks DNA synthesis, leading to cell death by apoptosis. 1PP is resistant to leucovorin, which is an antagonist of adriamycin and other chemotherapeutic agents. In vitro studies have shown that 1PP exhibits cytotoxicity against promyelocytic leukemia Hl-60 cells and Molt-4 cells.

Formula: C₁₀H₁₁NO

Purity: Min. 95%

Molecular weight: 161.2 g/mol

Ref: 3D-DFA12002